Korean J Obstet Gynecol.  1997 Feb;40(2):275-280.

The Association with Amniotic Fluid Interleukin-6 and Histologic Chorioamnionitis in Patients with Preterm Labor and Intact Membranes

Affiliations
  • 1Department of Obstetrics and Gynecology, College of Medicine, Ewha Medical Research Center, Ewha Womans University, Korea.
  • 2Department of Clinical Pathology,College of Medicine, Ewha Medical Research Center, Ewha Womans University, Korea.

Abstract


OBJECTIVE
Our purpose was to determine whether amniotic amniotic fluid concentrations of interleukin-6 are valuable in the prediction of histologic chorioamnionitis and in the prediction of perinatal morbidity. STUDY DESIGN: The relation among amniotic fluid imterleukin-6, histologic chorioamnionitis, and perinatal outcome was examined in patients with preterm labor and intact membranes. Interleukin-6 was determined by ELISA method.
RESULTS
Patients with histologic chorioamnionitis had significantly higher amniotic fluld interleukin-6 concentrations than patient without histologic chrioamnionitis. Also, patient with histologic chorioamnioitis had significantly higher perinatal morbidity rate than patient without histologic chorioamnionitis. An ammiotic fluld interlerkin-6 concentration had a sensitivity of 75% and a specificity of 62.5% in the diagnosis of preterm delivery.
CONCLUSION
Amniotic fluld interleukin-6 is a sensitive test for the prediction of histologic chorioamnionitis and of perinatal morbidity.

Keyword

Amniotic fluid; Interleukin-6; Perinatal morbidity; Histologic chorioamnionitis

MeSH Terms

Amniotic Fluid*
Chorioamnionitis*
Diagnosis
Enzyme-Linked Immunosorbent Assay
Female
Humans
Interleukin-6*
Membranes*
Obstetric Labor, Premature*
Pregnancy
Sensitivity and Specificity
Interleukin-6
Full Text Links
  • KJOG
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr