Korean J Urogenit Tract Infect Inflamm.  2014 Apr;9(1):44-49. 10.14777/kjutii.2014.9.1.44.

Analysis of Urinary Stone Composition: A Retrospective Single Center Study during the Last Five Years (2009-2013)

Affiliations
  • 1Department of Urology, Inje University College of Medicine, Busan, Korea. urokang@lycos.co.kr

Abstract

PURPOSE
Analysis of urinary stone composition is essential for treatment and prevention of urolithiasis. We evaluated the effect of age, gender, and stone location on urinary stone components during the last five years.
MATERIALS AND METHODS
We conducted a retrospective analysis of the medical records of 375 patients ranging in age from 15 years old to 93 years old (241 males and 134 females) who underwent conventional or endoscopic surgery, shock wave lithotripsy, or passed their stones spontaneously between 2009 and 2013. Stone analysis was performed using a chemical analysis method to determine the molecular composition of each stone.
RESULTS
Of the 375 patients with urolithiasis, 152 patients (40.5%) had predominantly calcium oxalate, 85 patients (21.5%) had uric acid, 17 patients (4.5%) had calcium phosphate, 17 patients (4.5%) had magnesium ammonium phosphate, 16 patients (4.3%) had calcium carbonate, and 86 patients (22.9%) had mixed stone type. There was a decreasing prevalence of calcium oxalate stone with age group (42.5% in young adult (20-39 years, n=40), 45.0% in adult (40-60 years, n=151), and 32.7% in elderly (> or =60 years, n=180) as opposed to increasing prevalence in uric acid stone (7.5% in young adult, 15.2% in adult and 32.2% in elderly). Uric acid stones were more common in males and in lower urinary tract stones.
CONCLUSIONS
In this study, the incidence of calcium oxalate decreased with age and that of uric acid increased with age and in male. In comparison of the results of previous studies for several decades, the incidence of uric acid increased in the last five years.

Keyword

Urinary calculi; Analysis; Uric acid

MeSH Terms

Adult
Aged
Ammonium Compounds
Calcium
Calcium Carbonate
Calcium Oxalate
Humans
Incidence
Lithotripsy
Magnesium
Male
Medical Records
Prevalence
Retrospective Studies*
Shock
Uric Acid
Urinary Calculi*
Urolithiasis
Young Adult
Calcium
Calcium Carbonate
Calcium Oxalate
Magnesium
Uric Acid

Reference

1. Saita A, Bonaccorsi A, Motta M. Stone composition: where do we stand? Urol Int. 2007; 79(Suppl 1):16–9.
Article
2. Kim Hh. Jo MK, Kwak C, Park SK, Yoo KY, Kang D, et al. Prevalence and epidemiologic characteristics of urolithiasis in Seoul, Korea. Urology. 2002; 59:517–21.
Article
3. Johnson CM, Wilson DM, O'Fallon WM, Malek RS, Kurland LT. Renal stone epidemiology: a 25-year study in Rochester, Minnesota. Kidney Int. 1979; 16:624–31.
Article
4. Smith LH. The medical aspects of urolithiasis: an overview. J Urol. 1989; 141:707–10.
Article
5. Alaya A, Nouri A, Belgith M, Saad H, Jouini R, Najjar MF. Changes in urinary stone composition in the Tunisian population: a retrospective study of 1,301 cases. Ann Lab Med. 2012; 32:177–83.
Article
6. Goldfarb DS, Coe FL. Prevention of recurrent nephrolithiasis. Am Fam Physician. 1999; 60:2269–76.
7. Kourambas J, Aslan P, Teh CL, Mathias BJ, Preminger GM. Role of stone analysis in metabolic evaluation and medical treatment of nephrolithiasis. J Endourol. 2001; 15:181–6.
Article
8. Basiri A, Taheri M, Taheri F. What is the state of the stone analysis techniques in urolithiasis? Urol J. 2012; 9:445–54.
9. Asper R. Epidemiology and socioeconomic aspects of urolithiasis. Urol Res. 1984; 12:1–5.
Article
10. Hesse A, Siener R. Current aspects of epidemiology and nutrition in urinary stone disease. World J Urol. 1997; 15:165–71.
Article
11. Daudon M, Donsimoni R, Hennequin C, Fellahi S, Le Moel G, Paris M, et al. Sex- and age-related composition of 10 617 calculi analyzed by infrared spectroscopy. Urol Res. 1995; 23:319–26.
Article
12. Byeon SS, Kim HH, Kim SW. Analysis of the urinary stone components using chemical analysis method. Korean J Urol. 1996; 37:179–86.
13. Ye SJ, Yoo ES, Park YK. Analysis of urinary stone components during the last two decades. Korean J Urol. 2007; 48:1285–88.
Article
14. Balaji KC, Menon M. Mechanism of stone formation. Urol Clin North Am. 1997; 24:1–11.
Article
15. Menon M, Mahle CJ. Oxalate metabolism and renal calculi. J Urol. 1982; 127:148–51.
Article
16. Finlayson B. Symposium on renal lithiasis. Renal lithiasis in review. Urol Clin North Am. 1974; 1:181–212.
17. Siener R, Glatz S, Nicolay C, Hesse A. The role of overweight and obesity in calcium oxalate stone formation. Obes Res. 2004; 12:106–13.
Article
18. Coe FL, Evan A, Worcester E. Kidney stone disease. J Clin Invest. 2005; 115:2598–608.
19. Abate N, Chandalia M, Cabo-Chan AV Jr, Moe OW, Sakhaee K. The metabolic syndrome and uric acid nephrolithiasis: novel features of renal manifestation of insulin resistance. Kidney Int. 2004; 65:386–92.
Article
20. Maalouf NM, Sakhaee K, Parks JH, Coe FL, Adams-Huet B, Pak CY. Association of urinary pH with body weight in nephrolithiasis. Kidney Int. 2004; 65:1422–5.
Article
21. Negri AL, Spivacow R, Del Valle E, Pinduli I, Marino A, Fradinger E, et al. Clinical and biochemical profile of patients with "pure" uric acid nephrolithiasis compared with "pure" calcium oxalate stone formers. Urol Res. 2007; 35:247–51.
Article
22. Zechner O, Pfluger H, Scheiber V. Idiopathic uric acid lithiasis: epidemiologic and metabolic aspects. J Urol. 1982; 128:1219–23.
Article
23. Poletto J, Harima HA, Ferreira SR, Gimeno SG. Hyperuricemia and associated factors: a cross-sectional study of Japanese-Brazilians. Cad Saude Publica. 2011; 27:369–78.
Article
24. Childs MA, Mynderse LA, Rangel LJ, Wilson TM, Lingeman JE, Krambeck AE. Pathogenesis of bladder calculi in the presence of urinary stasis. J Urol. 2013; 189:1347–51.
Article
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