Korean J Physiol Pharmacol.  1999 Feb;3(1):69-74.

Systemic injection of lidocaine induce expression of c-fos mRNA and protein in adult rat brain

Affiliations
  • 1Department of Dental Pharmacology, Wonkwang University School of Dentistry, Iksan, Chonbuk, 570-749 South Korea.
  • 2Department of Biochemistry, Kyunghee University School of Medicine, Seoul 130-702, South Korea.
  • 3Department of Pharmacology, Ajou University School of Medicine, Suwon, Kyungkido 442-749, South Korea.

Abstract

Both direct and indirect environmental stress to brain were increase the expression of transcription factor c-fos in various populations of neurons. In this study, we examined whether the intraperitoneal injections of lidocaine at doses inducing convulsion within 10 min increased the level of c-fos mRNA and protein in forebrain areas. In situ hybridization using (35S)UTP-labeled antisense c-fos, cRNA increased c-fos mRNA levels though hippocampal formation, piriform cortex, septum, caudate-putamen, neostriatum, and amygdala within 2 hr. In parallel with the mRNA expression, c-FOS protein immunoreactivity was also observed in the same forebrain areas. In contrast to the seizure activity and widespread neuronal degeneration following a kainate treatment, injections of lidocaine did not produce neuronal death within 3 days. The present study indicates that lidocaine induces convulsion and c-fos expression without causing neuro-toxicity.

Keyword

Transcription factor; c-fos mRNA and protein; Neurotoxicity

MeSH Terms

Adult*
Amygdala
Animals
Brain*
Hippocampus
Humans
In Situ Hybridization
Injections, Intraperitoneal
Kainic Acid
Lidocaine*
Neostriatum
Neurons
Prosencephalon
Rats*
RNA, Complementary
RNA, Messenger*
Seizures
Transcription Factors
Kainic Acid
Lidocaine
RNA, Complementary
RNA, Messenger
Transcription Factors
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