Korean J Thorac Cardiovasc Surg.  2001 Oct;34(10):745-753.

Efficacies of the Modified Ultrafiltration and Peritoneal Dialysis in Removing Inflammatory Mediators After Pediatric Cardiac Surgery

• Sung SC
• Jung MH

Abstract

BACKGROUND: Cardiopulmonary bypass induces an acute systemic inflammatory response mediated by complement activation and cytokine release. This response is likely to cause capillary leak syndrome and organ dysfunction in infants. Removing harmful cytokines and complement anaphylatoxins after cardiopulmonary bypass may attenuate this response. This study was conducted to see if the modified ultrafiltration and postoperative peritoneal dialysis can reduce plasma inflammatory mediators in pediatric cardiac surgery. MATERIAL AND METHOD: 30 infants (age 1.1 to 12.6 months) who underwent closures of ventricular septal defect using cardiopulmonary bypass (CPB) were enrolled in this study. These patients were divided into three groups; 10 patients selected randomly underwent modified ultrafiltration (Group U), 10 with small body weights (CONCLUSION
The effluents of peritoneal dialysis contained significant amount of proinflammatory cytokine, IL-6 and complement, C3a. However this study failed to elucidate the decrease in serum levels of these factors. The modified ultrafiltration also was not able to reduce the serum levels of C3a or IL-6 in our study as well.

Keyword

Cardiopulmonary bypass; Complement; C3a; Interleukin-6

MeSH Terms

Anaphylatoxins
Body Weight
Capillary Leak Syndrome
Cardiopulmonary Bypass
Complement Activation
Complement C3a
Complement System Proteins
Cytokines
Heart Septal Defects, Ventricular
Humans
Infant
Interleukin-6
Peritoneal Dialysis*
Plasma
Radioimmunoassay
Thoracic Surgery*
Ultrafiltration*
Anaphylatoxins
Complement C3a
Complement System Proteins
Cytokines
Interleukin-6