Korean J Urol.  1997 Dec;38(12):1261-1267.

Early Pathologic Changes of Kidney after Intraperitoneal Challenge with Sodium Oxalate in Rat

Affiliations
  • 1Yonsei University, Wonju college of Medicine, Wonju, Korea.

Abstract

To investigate the relationship between calcium oxalate stone formation and pathological change of the rat kidney, the early phases of calcium oxalate crystal formation in rat kidneys after intraperitoneal challenge with sodium oxalate were examined at various time interval. The number, size and distribution of the calcium oxalate particles, which were formed intraluminally in proximal tubule, depend on the pathological change according to the time interval after its injection. Tubular obstruction and dilatation due to cellular edema followed by necrosis of tubules and interstitial inflammation were related with increase in number and size of the calcium oxalate particles.

Keyword

calcium oxalate crystal; stone formation

MeSH Terms

Animals
Calcium Oxalate
Dilatation
Edema
Inflammation
Kidney*
Necrosis
Oxalic Acid*
Rats*
Sodium*
Calcium Oxalate
Oxalic Acid
Sodium
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