Korean J Urol.
1986 Apr;27(2):219-227.
Experimental Study on Hyperplasia of Urinary Bladder Epithelium Induced by N-Butyl-N-(4-Hydroxybutyl) Nitrosamine in Rats
- Affiliations
-
- 1Department of Urology, College of Medicine, Seoul National University, Seoul, Korea.
Abstract
- Hyperplasia of the uninary bladder epithelium in Wistar strain female rats after administration of 0.05% N-butyl-N-(4-hydroxybutyl) nitrosamine(BBN) was examined histologically and the effect of fat diet on the development of hyperplasia of the urinary bladder was studied. Hyperplasia of the urinary bladder epithelium was consistently observed after 4 weeks, and its extent increased with the period of BBN administration. Some of the hyperplastic lesion, showed a tendency to regress following removal of the carcinogenic stimuli. High fat diet has no effect on hyperplastic change of the urinary bladder in rats.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Ultrastructural Observations on Epithelial Changes of the Urinary Bladder in Rats Induced by N-Butyl-N-(4-Hydroxybutyl) Nitrosamine
- Immunohistochemical Study with Carcinoembryonic Antigen in Experimental Bladder Tumor Induced by Administration of N-butyl-N-(4-hydroxybutyl)-nitrosamine
- Effect of intraperitoneal injection of single chemotherapeutic agent on rat bladder carcinogenesis induced by N-butyl-N-(4-hydroxybutyl) nitrosamine
- The significance of nucleolar organizer regions in bladder epithelial lesions induced by N-butyl-N-(4-hydroxybutyl)nitrosamine in rat
- Effect of Intraperitoneal and Intravesical Bacillus Calmette-Guerin on Bladder Carcinogenesis in Rats Induced by N-butyl-N-(4-hydroxybutyl) nitrosamine
