Korean J Urol.  1985 Dec;26(6):595-604.

A Cytogenetic Study in Patients with Suspected Y Chromosomal Abnormalities

• Kim KM
• Moon SY

Abstract

A chromosomal study was performed in a tota1 of 98 patients with suspected Y chromosomal abnormalities during past 1-1/2 years (Feb. 1984 -Aug. 1985). Karyotypes were obtained using short-term blood culture. Of these 43 (44%) patients had abnormal chromosome complements. Among all patients with chromosome abnormalities, 88% (38/43) had aberrations of chromosome number and others 32% (5/42) had aberrations of chromosome structure. The results of chromosomal study in various groups showed as follows: l. In 34 cases of Klinefelter's syndrome, there were 31 cases (91%) of 47,XXY, 1 case of 46,XX,47, XXY, 1 case of 48, XXXXY and 1 case of 46,XX/46,XY/47,XXY. 2. AII 3 cases of mixed gonadal dysgenesis had 45,X/46,XY. 3. l case of true hermaphroditism had 46,XX. 4. Z cases of male Turner`s syndrome, 6 cases of male pseudohermaphroditism and 1 case of agonadism had 46,XY. 5. In 6 cases of female pseudohermaphroditism, there were 4 cases of 46,XX, 1 case of 46,XX, inv(9) and 1 case of 46,XX, t (14q, 21q). 6. In 28 cases of hypogonadism (excluding Klinefelter`s syndrome), there were 25 cases (89%) of 46, XY, 1 case of 46,XY, 15s-, 1 case of 46,XY, inv(9) and 1 case of 46,XY/46, XY,t(7 : 14). 7. 1 case of cryptorchism had 47,XY,+21. 8. All of 5 cases of hypospadia, 5 cases of cryptorchism, 3 cases of hypospadia with cryptorchism, 2 cases of small phallus, 1 case of concealed penis and 1 case of normal male who wanted to correct his registered sex had 46,XY.

Keyword

cytogenetics; chromosomal abnormality; Y chromosome

MeSH Terms

46, XX Disorders of Sex Development
46, XY Disorders of Sex Development
Chromosome Aberrations*
Chromosome Structures
Complement System Proteins
Cryptorchidism
Cytogenetics*
Down Syndrome
Female
Gonadal Dysgenesis, Mixed
Humans
Hypogonadism
Hypospadias
Karyotype
Klinefelter Syndrome
Male
Ovotesticular Disorders of Sex Development
Penis
Y Chromosome
Complement System Proteins