Anesth Pain Med.  2014 Jul;9(3):205-208.

Cardiac arrest following reversal of muscle relaxation by pyridostigmine: A case report

Affiliations
  • 1Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. swkoo@amc.seoul.kr
  • 2Department of Anesthesiology and Pain Medicine, Hallym University College of Medicine, Seoul, Korea.

Abstract

The anticholinesterase pyridostigmine is usually used as a reversal agent of non-depolarizing muscle relaxants in general anesthesia. Most adverse muscarinic effects of anticholinesterases are controlled by anticholinergics; however, there is still a potential for fatal cardiac complications. We report a case of cardiac arrest associated with coronary vasospasm that developed during emergence from general anesthesia in a 61-year-old male patient undergoing uvulopalatopharyngoplasty with preoperatively undiagnosed coronary vasospastic angina. Anticholinesterases should be administered with caution for neuromuscular blockade reversal, especially in patients with coronary vasospastic angina.

Keyword

Cardiac arrest; Coronary spasm; Pyridostigmine; Reversal of neuromuscular block

MeSH Terms

Anesthesia, General
Cholinergic Agents
Cholinergic Antagonists
Cholinesterase Inhibitors
Coronary Vasospasm
Heart Arrest*
Humans
Male
Middle Aged
Muscle Relaxation*
Neuromuscular Blockade
Neuromuscular Nondepolarizing Agents
Pyridostigmine Bromide*
Cholinergic Agents
Cholinergic Antagonists
Cholinesterase Inhibitors
Neuromuscular Nondepolarizing Agents
Pyridostigmine Bromide
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