J Korean Soc Coloproctol.  2002 Feb;18(1):22-29.

Immunohistochemical Study of KAI1, a Tumor Metastasis Suppressor Gene, Expression in Rectal Cancer

Affiliations
  • 1Department of Surgery Yonsei University Wonju College of Medicine, Wonju, Korea. iykim@wonju.yonsei.ac.kr
  • 2Department of Pathology Yonsei University Wonju College of Medicine, Wonju, Korea.

Abstract

PURPOSE: KAI1/CD82 gene is a recently identified metastasis suppressor gene on human chromosome 11p11.2. Alteration to or reduction of this molecule may allow tumor cells to invade the surrounding tissue and blood vessels. Decreased KAI1 expression seems to be involved in the progression of human prostate, lung and possibly breast cancer, and recently has been demonstrated in several colorectal cell lines. The aim of this study is to determine whether the gene is altered to investigate it in the progression and metastatic process of rectal carcinoma. In addition, its prognostic significance is also evaluated.
METHODS
Total 108 tumor samples from primary, metastatic rectal carcinoma were prepared for immunohistochemical study with an anti-KAI1 polyclonal antibody. To analysis the correlation between KAI1 expression and clinicopathological parameter and to evaluate for relation expression and survival.
RESULTS
Decrease of KAI1 protein expression was associated with the depth of invasion of tumor (P < 0.0001) and node metastasis (P < 0.05). Liver metastasis showed reduced KAI1 expression when compared with their corresponding primary tumor. Although there was a trend for deteriorating survival from patients with KAI1-positive tumors to those with KAI1-decreased and -negative tumors, it was not significant statistically (P CONCLUSIONS
KAI1 may play a role in the malignant progression of rectal carcinoma through the down-regulation of expression. KAI1 might influence the metastatic ability of human rectal cancer. And its prognostic significance needs further investigation with a larger number of cases.

Keyword

Rectal carcinoma; Metastasis suppressor gene; KAI1 gene; Immunohistochemical study

MeSH Terms

Antigens, CD82
Blood Vessels
Breast Neoplasms
Cell Line
Chromosomes, Human
Down-Regulation
Genes, Tumor Suppressor*
Humans
Liver
Lung
Neoplasm Metastasis*
Prostate
Rectal Neoplasms*
Antigens, CD82
Full Text Links
  • JKSC
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr