Korean J Perinatol.  2015 Jun;26(2):114-120. 10.14734/kjp.2015.26.2.114.

Perinatal Outcomes of Pregnancy with Assisted Reproductive Technology

  • 1Department of Obstetrics and Gynecology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea. doctor-joon@hanmail.net


Assisted reproductive technology (ART) is defined as any treatment and procedure associated with the handling of human oocytes, sperms or embryos for the purpose of establishing a pregnancy. As the use of ART has been dramatically increasing over 3 decades and the number of babies born by ART are increasing, it is important to consider perinatal outcomes of pregnancies with ART including structural abnormalities, growth and development, as well as the clinical pregnancy rate and the live-birth rate with regard to the parameters assessing the success of ART. Clinicians should be aware of maternal and perinatal outcomes in pregnancy with ART and infertile couples considering ART should be thoroughly counseled on these issues. In this article, the perinatal outcomes of pregnancy with ART will be reviewed.


Assisted reproductive technology; In vitro fertilization; Multifetal pregnancy; Long-term outcome; Perinatal outcome

MeSH Terms

Embryonic Structures
Family Characteristics
Fertilization in Vitro
Growth and Development
Pregnancy Rate
Reproductive Techniques, Assisted*



1. ACOG Committee on Obstetric Practice, ACOG Committee on Gynecologic Practice, ACOG Committee on Genetics. ACOG Committee Opinion #324: Perinatal risks associated with assisted reproductive technology. Obstet Gynecol. 2005; 106:1143–6.
2. Committee for Assisted Reproductive Technology Korean Society of Obstetrics and Gynecology. Choi YM, Chun SS, Han HD, Hwang JH, Hwang KJ, et al. Current status of assisted reproductive technology in Korea, 2009. Obstet Gynecol Sci. 2013; 56:353–61.
3. Poon WB, Lian WB. Perinatal outcomes of intrauterine insemination/clomiphene pregnancies represent an intermediate risk group compared with in vitro fertilisation/intracytoplasmic sperm injection and naturally conceived pregnancies. J Paediatr Child Health. 2013; 49:733–40.
4. 통계청. 2009년 출생통계 결과. 2010.
5. Gunningham FG, Leveno KJ, Bloom SL, Spong CY, Dashe JS, Hoffman BL, et al. Multifetal pregnancy. Gunningham FG, Leveno KJ, Bloom SL, Spong CY, Dashe JS, Hoffman BL, editors. editors.Williams Obstetrics. 24th ed.New York: McGraw-Hill Education;2014. p. 891–924.
6. Allen VM, Wilson RD, Cheung A, Genetics Committee of the Society of Obstetricians and Gynaecologists of Canada (SOGC), Reproductive Endocrinology Infertility Committee of the Society of Obstetricians and Gynaecologists of Canada (SOGC). Pregnancy outcomes after assisted reproductive technology. J Obstet Gynaecol Can. 2006; 28:220–50.
7. Chung K, Coutifaris C, Chalian R, Lin K, Ratcliffe SJ, Castelbaum AJ, et al. Factors influencing adverse perinatal outcomes in pregnancies achieved through use of in vitro fertilization. Fertil Steril. 2006; 86:1634–41.
8. Ombelet W, Martens G, De Sutter P, Gerris J, Bosmans E, Ruyssinck G, et al. Perinatal outcome of 12,021 singleton and 3108 twin births after non-IVF-assisted reproduction: a cohort study. Hum Reprod. 2006; 21:1025–32.
9. Allen C, Bowdin S, Harrison RF, Sutcliffe AG, Brueton L, Kirby G, et al. Pregnancy and perinatal outcomes after assisted reproduction: a comparative study. Ir J Med Sci. 2008; 177:233–41.
10. Society of Obstetricians annd Gynaecologists of Canada. Okun N, Sierra S. Pregnancy outcomes after assisted human reproduction. J Obstet Gynaecol Can. 2014; 36:64–83.
11. van Heesch MM, Evers JL, Dumoulin JC, van der Hoeven MA, van Beijsterveldt CE, Bonsel GJ, et al. A comparison of perinatal outcomes in singletons and multiples born after in vitro fertilization or intracytoplasmic sperm injection stratified for neonatal risk criteria. Acta Obstet Gynecol Scand. 2014; 93:277–86.
12. Cakar E, Kavuncuoglu S, Aldemir EY, Cetinkaya M, Guzeltas A, Arslan G. Features of multiple pregnancies obtained by in vitro fertilization or spontaneously. Pediatr Int. 2014; 56:735–41.
13. Pinborg A. IVF/ICSI twin pregnancies: risks and prevention. Hum Reprod Update. 2005; 11:575–93.
14. 보건복지부. '체외수정시술 의학적 기준 가이드라인'. In: 2013년도 모자보건사업 안내. 2012. 142–3.
15. Practice Committee of American Society for Reproductive Medicine, Practice Committee of Society for Assisted Reproductive Technology. Criteria for number of embryos to transfer: a committee opinion. Fertil Steril. 2013; 99:44–6.
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