Korean J Clin Pathol.  1997 Oct;17(5):694-702.

Two Cases of Transient Aplastic Crisis Associated with Human Parvovirus Bl9 Infection in Hereditary Spherocytosis and Hereditary Elliptocytosis

• Choi YJ
• Kil YK
• Cho SR
• Kim HJ
• Baick SH

Abstract

Among the causes of pure red cell aplasia, human parvovirus B19 has been shown to be cytotoxic to erythroid progenitor cells in the bone marrow associated with chronic hemolytic anemia with rapidly dividing erythroids and persistently to be suppression of erythropoiesis in immunocompromised individuals related with failure to produce neutralizing antibody to the virus. In a patient with hereditary spherocytosis presenting acute onset of reticulocytopenia during hospitalization, who had shown severe anemia and prodromal symptoms including fever, fatigue and dizziness, infection of parvovirus Bl9 was proven by the presence of IgM and IgG antibodies to parvovirus Bl9, the detection of viral DNA using PCR technique in her serum and the decreased erythroid cells, especially late normoblasts in bone marrow, Also in the other who was diagnosed as hereditary elliptocytosis and complained of fever, headache, abdominal pain and diarrhea, an episode of reticulocytopenia and the nearly absence of late normoblasts in the bone marrow were observed. IgM antibodies to parvovirus Bl9 and the viral DNA were detected in her serum, too.

MeSH Terms

Abdominal Pain
Anemia
Anemia, Hemolytic
Antibodies
Antibodies, Neutralizing
Bone Marrow
Diarrhea
Dizziness
DNA, Viral
Elliptocytosis, Hereditary*
Erythroblasts
Erythroid Cells
Erythroid Precursor Cells
Erythropoiesis
Fatigue
Fever
Headache
Hospitalization
Humans*
Immunoglobulin G
Immunoglobulin M
Parvovirus B19, Human
Parvovirus*
Polymerase Chain Reaction
Prodromal Symptoms
Red-Cell Aplasia, Pure
Antibodies
Antibodies, Neutralizing
DNA, Viral
Immunoglobulin G
Immunoglobulin M