Kosin Med J.  2014 Jun;29(1):75-79. 10.7180/kmj.2014.29.1.75.

A Case of Adult onset Bartter Syndrome with Nephrocalcinosis

Affiliations
  • 1Department of Internal Medicine, Dae-Dong Hospital, Busan, Korea. 95240226@naver.com
  • 2Department of Internal Medicine, College of Medicine, Kosin University, Busan, Korea.

Abstract

Bartter syndrome is a renal tubular defect in electrolyte transport characterized by hypokalemia, metabolic alkalosis, hyperreninemia, hyperaldosteronism, normal blood pressure, and other clinical symptoms. As a clinical and genetical heterogeneous disorder, this syndrome can be classified into two clinical variants, antenatal Bartter syndrome and classic Bartter syndrome according to the onset age. Nephrocalcinosis is common in antenatal Bartter syndrome, but is rare in classic Bartter syndrome. It can also be classified into five genetic subtypes by the underlying mutant gene, all of which are expressed in the tubular epithelial cells of the thick ascending limb of the loop of Henle. Patients with Bartter syndrome type 1, 2 and 4 present at a younger age than classic Bartter syndrome type 3. We have experienced a case of Bartter syndrome with nephrocalcinosis in a 42-year-old woman diagnosed by biochemical and radiologic studies. We had successful response with potassium chloride and spironolactone.

Keyword

Bartter Syndrome; Hypokalemia; Metabolic Alkalosis; Nephrocalcinosis

MeSH Terms

Adult*
Age of Onset
Alkalosis
Bartter Syndrome*
Blood Pressure
Epithelial Cells
Extremities
Female
Humans
Hyperaldosteronism
Hypokalemia
Loop of Henle
Nephrocalcinosis*
Potassium Chloride
Spironolactone
Potassium Chloride
Spironolactone
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