Brain Tumor Res Treat.  2015 Apr;3(1):39-43. 10.14791/btrt.2015.3.1.39.

Thrombosed Large Middle Cerebral Artery Aneurysm Mimicking an Intra-Axial Brain Tumor: Case Report and Review of Literature

• Kim YJ
• Jeun SS
• Park JH

• KMID: 1882009
• DOI: http://doi.org/10.14791/btrt.2015.3.1.39

Abstract

This case report presents a fully thrombosed large aneurysm of middle cerebral artery mimicking an intra-axial brain tumor in a 54-year-old male patient. A small mass like lesion was found incidentally in right frontal area. Brain magnetic resonance image showed dark signal intensity on T2-weighted images and peripheral high signal intensity on T1-weighted images with peripheral rim enhancement. We considered intra-axial tumors such as glioma or metastatic tumor as a differential diagnosis. The lesion was approached transcortically, and intraoperatively, the lesion was found to be a large thrombosed aneurysm originating from the lateral lenticulostriate artery of right middle cerebral artery. One vascular clip was applied at the parent artery, and the thrombosed aneurysm was totally removed. There have been many reports of other intracranial lesions wrongly diagnosed as intracranial neoplasms. And thrombosed aneurysms mimicking intracranial neoplasm have been reported in 4 cases previously. According to those case reports, there were no efficient imaging tools to differentiate between these thrombosed aneurysms and intracranial neoplasms. We reviewed those reports and considered about the efficient method to diagnosed accurately before surgery. To sum up, when a patient presents with an intracranial lesion lying on the course of major or distal cerebral arteries, the surgeon should have thrombosed aneurysm in mind as one of the differential diagnosis and be prepared when surgically treating such lesions.

Keyword

Intracranial aneurysm; Aneurysm; Brain neoplasms; Thrombosis; Diagnostic errors

MeSH Terms

Aneurysm
Arteries
Brain
Brain Neoplasms*
Cerebral Arteries
Deception
Diagnosis, Differential
Diagnostic Errors
Glioma
Humans
Intracranial Aneurysm*
Male
Middle Aged
Middle Cerebral Artery
Parents
Thrombosis

Figure

• 

  Fig. 1 Computed tomography (CT) scan of brain. A: Well-defined mass showing high density, sized 11 mm in diameter, located in right frontal area is observed in initial CT, 7 years ago. B: Recent CT scan shows enlargement of the mass-like lesion which was noted previously, sized in 19×15 mm, with surrounding edema.

• 

  Fig. 2 Magnetic resonance images (MRI) of brain. A: T2-weighted axial MRI. B: Fluid-attenuated inversion recovery (FLAIR) axial MRI. C: Gadolinium enhanced T1-weighted coronal MRI. D: Non-enhanced T1-weighted axial MRI. E: Gadolinium-enhanced T1-weighted axial MRI. F: Gadolinium-enhanced T1-weighted sagittal MRI. A round mass with surrounding edema is noted in right frontal gray matter. It shows peripheral rim enhancement. Dark signal intensity on T2-weighted image (A) and FLAIR image (B) and peripheral high signal intensity on T1-weighted image (D) suggests hemangioma as a differential diagnosis to rule out.

• 

  Fig. 3 Intraoperative photographs showing a large thrombosed aneurysm. A: Yellowish round mass (black arrow) was observed after navigation-guided transcortical approach at right frontal area. B: Small artery (white arrow) connected to the mass revealed under the mass. It seemed to be one of the lenticulostriate arteries. C: Vascular clip was applied at the parent artery and the distal end (white arrow) was coagulated by bipolar coagulator. D: The mass was totally excised, and there was no other complication at the operation site.

• 

  Fig. 4 Gross images of the removed mass. A: Gross image of the mass shows yellowish slithery surface as a vessel wall. B: Cross section of the mass shows thrombus material fully embeded in the aneurysm.

• 

  Fig. 5 Postoperative images. A: CT scan shows postoperative changes with vascular clip noted in right sylvian fissure. B: In the MRI, the mass is totally removed and vascular clip as applied parallel to the M1 segment of right middle cerebral artery. There was no other surgical complications.

• 

  Fig. 6 Right internal carotid angiogram (A) and three-dimensional reconstructed image (B) shows vascular clip applied parallel to the M1 segment of right middle cerebral artery and complete removal of thrombosed aneurysm. The arrow indicates the vascular clip applied site. There was no other vascular abnormalities.

Reference

1. Heros RC, Fritsch MJ. Surgical management of middle cerebral artery aneurysms. Neurosurgery. 2001; 48:780–785.

2. Rinne J, Hernesniemi J, Niskanen M, Vapalahti M. Analysis of 561 patients with 690 middle cerebral artery aneurysms: anatomic and clinical features as correlated to management outcome. Neurosurgery. 1996; 38:2–11.

3. Brownlee RD, Tranmer BI, Sevick RJ, Karmy G, Curry BJ. Spontaneous thrombosis of an unruptured anterior communicating artery aneurysm. An unusual cause of ischemic stroke. Stroke. 1995; 26:1945–1949.

4. Jellinger K. Pathology of intracerebral hemorrhage. Zentralbl Neurochir. 1977; 38:29–42.

5. Wiebers DO, Whisnant JP, Huston J 3rd, et al. Unruptured intracranial aneurysms: natural history, clinical outcome, and risks of surgical and endovascular treatment. Lancet. 2003; 362:103–110.

6. Hosoda K, Fujita S, Kawaguchi T, Shose Y, Hamano S. Saccular aneurysms of the proximal (M1) segment of the middle cerebral artery. Neurosurgery. 1995; 36:441–446.

7. Gandhi CD, Gilad R, Patel AB, Haridas A, Bederson JB. Treatment of ruptured lenticulostriate artery aneurysms. J Neurosurg. 2008; 109:28–37.

8. Morley TP, Barr HW. Giant intracranial aneurysms: diagnosis, course, and management. Clin Neurosurg. 1969; 16:73–94.

9. Whittle IR, Dorsch NW, Besser M. Spontaneous thrombosis in giant intracranial aneurysms. J Neurol Neurosurg Psychiatry. 1982; 45:1040–1047.

10. Black SP, German WJ. Observations on the relationship between the volume and the size of the orifice of experimental aneurysms. J Neurosurg. 1960; 17:984–990.

11. Jaimovich SG, Thea VC, Guevara M, Gardella JL. Cavernous sinus tuberculoma mimicking a neoplasm: case report, literature review, and diagnostic and treatment suggestions for tuberculomas in rare locations. Surg Neurol Int. 2013; 4:158.

12. Grayeli AB, Redondo A, Salama J, Rey A. Tuberculoma of the cavernous sinus: case report. Neurosurgery. 1998; 42:179–181.

13. Woo PY, Ko NM, Chan KY. Thrombosed large distal posterior inferior cerebellar artery aneurysm mimicking an infratentorial ependymoma. Case Rep Neurol Med. 2014; 2014:435953.

14. Päsler D, Baldauf J, Runge U, Schroeder HW. Intrameatal thrombosed anterior inferior cerebellar artery aneurysm mimicking a vestibular schwannoma. J Neurosurg. 2011; 114:1057–1060.

15. Fifi JT, Komotar R, Meyers P, Khandji A, Tanji K, Connolly ES. Restricted diffusion in a thrombosed anterior cerebral artery aneurysm mimicking a dermoid cyst. J Neuroimaging. 2012; 22:85–88.

16. Lan ZG, Ma L, Duan J, You C. A fully thrombosed giant posterior inferior cerebellar aneurysm mimicking an intracranial tumour in a child. Br J Neurosurg. 2012; 26:888–890.