Korean J Otolaryngol-Head Neck Surg.  2000 Apr;43(4):416-420.

Autogenous Mucosa-Lined Tracheal Prosthesis

Affiliations
  • 1Department of Otorhinolaryngology-Head and Neck Surgery, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea.
  • 2Department of Internal Medicine, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea.
  • 3Department of Biomedical Engineering, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea.
  • 4Department of Thoracic Surgery, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea.

Abstract

BACKGROUND AND OBJECTIVES: Reliable prosthetic or tissue graft of trachea for reconstruction of large, circumferential tracheal defect has not yet been developed. The major limitations in this area have been anastomotic dehiscence and stenosis, which are attributed to poor epithelialization and vascularization of prosthetic grafts. MATERIALS AND METHOD: We developed a new tracheal prosthesis which has a viable lined mucosa and is well-vascularized. The prosthesis consists of Prolene mesh reinforced with polypropylene rings, and is coated with gelatin. We lined the luminal surface of the prosthesis with transplanted autogenous oral mucosa and wrapped the prosthesis with greater omentum. Animal experiments were performed using 8 adult Mongrel dogs.
RESULTS
The transplanted mucosa and the greater omentum that was wrapped were tightly adhered to the prosthesis to make a single unit within two weeks. The mucosa survived well, having been vascularized by new vessels from the greater omentum, and showed normal histology.
CONCLUSION
We concluded that this highly biocompatible tracheal prosthesis could be very useful for stage4 reconstruction of tracheal defects.

Keyword

Tracheal prosthesis; Prolene mesh; Autologous mucosa transplantation; Omental wrapping

MeSH Terms

Adult
Animal Experimentation
Animals
Constriction, Pathologic
Dogs
Gelatin
Humans
Mouth Mucosa
Mucous Membrane
Omentum
Phenobarbital
Polypropylenes
Prostheses and Implants*
Trachea
Transplants
Gelatin
Phenobarbital
Polypropylenes
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