Korean J Gastrointest Endosc.
2001 Dec;23(6):461-465.
A Case of Esophageal Involvement of Cicatrical Pemphigoid
- Affiliations
-
- 1Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea. kumcge@cohllian.net
- 2Department of Institute of Digestive Disease and Nutrition Korea University College of Medicine, Seoul, Korea.
Abstract
- Cicatrical pemphigoid is regarded as a chronic, autoimmune subepithelial blistering disease of mucous membranes in which lesions often heal with scar formation. Cicatrical pemphigoid typically involves the oral and/or ocular mucosa but may affect the nasal, pharyngeal, laryngeal, esophageal, anogenital regions as well. Immunopathologic studies have shown that patients with cicatrical pemphigoid typically have autoantibodies directed against basement membrane antigens and that they demonstrate continuous deposits of immunoglobulins (IgG, A), complement components and fibrin along the basement membrane. A 69-year-old female was admitted with chief complaints of hoarseness, dyspnea, multiple painful oral ulcer and vesiculobullous skin lesion on upper trunk. During admission, dysphagia and epigastric discomfort was developed. Endoscopic examination revealed multiple erosion and ulcerative lesion with scar formation. Immunopathologic studies showed that linear deposit of IgG, A, C3 along the basement membrane zone. We report a case of cicatrical pemphigoid with esophageal involvement with brief review of literature.
Keyword
MeSH Terms
-
Aged
Autoantibodies
Basement Membrane
Blister
Cicatrix
Complement System Proteins
Deglutition Disorders
Dyspnea
Esophagus
Female
Fibrin
Hoarseness
Humans
Immunoglobulin G
Immunoglobulins
Mucous Membrane
Oral Ulcer
Pemphigoid, Bullous*
Skin
Ulcer
Autoantibodies
Complement System Proteins
Fibrin
Immunoglobulin G
Immunoglobulins
