Korean J Gastrointest Endosc.
2000 Jul;21(1):549-553.
A Case of Idiopathic Myelofibrosis Causing an Esophageal Variceal Hemorrhage
- Affiliations
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- 1Department of Internal Medicine, Eulji University School of Medicine, Daejeon, Korea.
- 2Department of Clinical Pathology, Eulji University School of Medicine, Daejeon, Korea.
- 3Department of Radiology, Eulji University School of Medicine, Daejeon, Korea.
- 4Department of Pathology, Eulji University School of Medicine, Daejeon, Korea.
Abstract
- Idiopathic Myelofibrosis (IMF), a clonal disorder of a multipotent hemtopoietic progenitor cell of unknown etiology, is characterized by massive splenomegaly, leukoerythroblastic blood changes, and bone marrow fibrosis. Portal hypertension occurs in approximately 10% of patients with IMF. Alsom there mey be bleeding from esophageal varices. A 59-year-old woman was admitted with intermittent abdominal distension and melena. An esophagogastroduodenoscopy revealed extensive esophageal varices with red colored signs, and subsequently esophageal variceal ligation was performed. Marked splenomegaly and ascites was observed through abdominal US and MRI scan. Bone marrow biopsy revealed an increase in reticulin and fibrosis. Extramedullary hematopoiesis and sinusoidal change were observed in the liver biopsy specimen. This case of IMF causing an esophageal variceal hemorrhage is herein reported.
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