Korean J Gastrointest Endosc.
1998 Aug;18(4):561-566.
A Case of Primary Gastric Amyloidosis Diagnosed by Endoscopy
- Affiliations
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- 1Division of Gastroenterology, Department of Internal Medicine, Sung Kyun Kwan University College of Medicine Samsung Medical Center, Seoul, Korea.
- 2Division of Gastroenterology, Department of Pathology, Sung Kyun Kwan University College of Medicine Samsung Medical Center, Seoul, Korea.
Abstract
- Amyloidosis is characterized by deposition of amyloid, which is resistant to proteolysis & phagocytosis, in intercellular spaces & vascular walls. The amyloid deposition provokes dysfunction of an accumulated organ & displays variable clinical symptoms depending upon the involved organ. A diagnosis is rendered through a biopsy of the affected organ, followed by staining using congo red which reveals an apple greenish refractile birefringence via polarizing microscopy. Using an electro-microscopy specific filaments can be found. Amyloidosis is classified into primary amyloidosis, composed of light chain filaments (AL) and secondary amyloidosis, comprised of A protain (AA). The AL type of amyloidosis shows deposition of amyloid in muscularis mucosa & muscularis externa. Priunary amyloidosis on the other hand, is relatively rare. We experienced primary stornach amyloidosis (AL), which was mistaken for stomch cancer.
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