Korean J Dermatol.  1995 Jun;33(3):540-545.

A Case of Epidermolysis Bullosa Acquisita

• No authors listed

Abstract

Epidermolysis bullosa acquisita (EBA) is rare chronic subepidermal bullous disease characterized by skin fragility, trauma-induced or spontaneous blisters, erosions, scars and milia. It is an autoimmune disease with autoantibodies to type VII collagen. A 54-year-old female had marked skin fragility, scatteed erythematous tense bullae, hyperpigmentations, and milia on the whole body including oral mucosa. On the histopathologic finding, the bulla showed a subepidermal cleavage and polymorphous inflammatory cell infiltrates on the papillary dermis. On direct immunofluorescence, linear deposits of IgG and C3 were observed along the basement membrane zone. Indirect immunofluorescence technique on the saltsplit skin demonstrated linear fluorescence only on the dermal side of the split skin.

MeSH Terms

Autoantibodies
Autoimmune Diseases
Basement Membrane
Blister
Cicatrix
Collagen Type VII
Dermis
Epidermolysis Bullosa Acquisita*
Epidermolysis Bullosa*
Female
Fluorescence
Fluorescent Antibody Technique, Direct
Fluorescent Antibody Technique, Indirect
Humans
Immunoglobulin G
Middle Aged
Mouth Mucosa
Skin
Transcutaneous Electric Nerve Stimulation
Autoantibodies
Collagen Type VII
Immunoglobulin G