Diabetes Metab J.  2011 Oct;35(5):451-457. 10.4093/dmj.2011.35.5.451.

The Role of the Sweet Taste Receptor in Enteroendocrine Cells and Pancreatic beta-Cells

• Kojima I
• Nakagawa Y

• KMID: 1857499
• DOI: http://doi.org/10.4093/dmj.2011.35.5.451

Abstract

The sweet taste receptor is expressed in taste cells located in taste buds of the tongue. This receptor senses sweet substances in the oral cavity, activates taste cells, and transmits the taste signals to adjacent neurons. The sweet taste receptor is a heterodimer of two G protein-coupled receptors, T1R2 and T1R3. Recent studies have shown that this receptor is also expressed in the extragustatory system, including the gastrointestinal tract, pancreatic beta-cells, and glucose-responsive neurons in the brain. In the intestine, the sweet taste receptor regulates secretion of incretin hormones and glucose uptake from the lumen. In beta-cells, activation of the sweet taste receptor leads to stimulation of insulin secretion. Collectively, the sweet taste receptor plays an important role in recognition and metabolism of energy sources in the body.

Keyword

beta-cell; Calcium; Cyclic AMP; Glucose-dependent insulinotropic peptide; Glucagon-like peptide-1; Glucose incretin; Glucose transporter; Insulin; Sweet taste receptor

MeSH Terms

Brain
Calcium
Cyclic AMP
Enteroendocrine Cells
Gastric Inhibitory Polypeptide
Gastrointestinal Tract
Glucagon-Like Peptide 1
Glucose
Glucose Transport Proteins, Facilitative
Incretins
Insulin
Intestines
Mouth
Neurons
Taste Buds
Tongue
Calcium
Cyclic AMP
Gastric Inhibitory Polypeptide
Glucagon-Like Peptide 1
Glucose
Glucose Transport Proteins, Facilitative
Incretins
Insulin