Korean J Asthma Allergy Clin Immunol.  2006 Jun;26(2):155-158.

A Case of Human Insulin Allergy Induced by Rapid Acting Human Recombinant Insulin, Humulin-R

Abstract

Since human recombinant insulin applied, insulin allergy is rare. We experienced a case of human insulin allergy in a 31-year-old female diabetic patient who was well controlled by Humulin 70/30 (Lilly France S.A.S) composed of rapid Humulin-R and intermediate Humulin-N. Her symptoms such as whole body itching, dyspnea, nausea, and lightheadedness occurred 1 or 2 minutes after injection, which completely recovered around 30 minutes later. Before this event, she also experienced urticaria on injection site several times. Skin prick test with Humulin 70/30, Humulin-R, Humulin-N, Novolet-R, Novolet-N, Protamin, and Zinc was done. Only Humulin 70/30 and Humulin-R showed strong positive reactions. So she was diagnosed as Humulin-R allergy.

MeSH Terms

Adult
Dizziness
Dyspnea
Female
France
Humans*
Hypersensitivity*
Insulin*
Insulin, Regular, Human
Nausea
Pruritus
Skin
Urticaria
Zinc
Insulin
Insulin, Regular, Human
Zinc