Immune Netw.  2005 Dec;5(4):247-251. 10.4110/in.2005.5.4.247.

Inhibition of Cell Migration by Corticotropin-Releasing Hormone (CRH) in Human Natural Killer Cell Line, NK-92MI

  • 1Department of Life Science, Sookmyung Women's University, Seoul, Korea.
  • 2Department of Plastic Surgery, Samsung Medical Center, Sunhkyunkwan University School of Medicine, Seoul, Korea.


Natural killer (NK) cells are CD3 (-) CD14 (-) CD56 (+) lymphocytes. They play an important role in the body's innate immune response. They can induce spontaneous killing of cancer cells or virus-infected cells via the Fas/Fas ligand or the granzyme/perforin systems. The corticotropin-releasing hormone (CRH) is an important regulator for the body's stress response. It promotes proliferation and migration of various cancer cells through the CRH type 1 receptor under stress, and also inhibits NK or T cell activity. However, the relationship of CRH and NK cell migration to the target has not been confirmed. Herein, we study the effect of CRH on NK cell migration. METHODS: We used the human NK cell line, NK-92MI, and tested the expression of CRH receptor type 1 on NK-92MI by RT-PCR. This was to examine the effect of CRH on tumor and NK cell migration, thus NK cells (NK-92MI) were incubated with or without CRH and then each CRH treated cell's migration ability compared to that of the CRH untreated group. RESULTS: We confirmed that CRH receptor type 1 is expressed in NK-92MI. CRH can decrease NK cell migration in a time-/dose-dependent manner. CONCLUSION: These data suggest CRH can inhibit NK cell migration to target cells.


Corticotropin releasing hormone (CRH); NK cell; migration

MeSH Terms

Cell Movement*
Corticotropin-Releasing Hormone*
Immunity, Innate
Killer Cells, Natural*
Receptors, Corticotropin-Releasing Hormone
Corticotropin-Releasing Hormone
Receptors, Corticotropin-Releasing Hormone
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