J Korean Soc Clin Toxicol.  2015 Jun;13(1):19-24.

Effect of Alcohol on Death Rate in Organophosphate Poisoned Patients

Affiliations
  • 1Department of Emergency Medicine, Hallym University Sacred Heart Hospital, Hallym University, Pyeongchon, Republic of Korea. aukawa@hallym.or.kr
  • 2Emergency Medicine, Graduate School of Hallym University, Republic of Korea.
  • 3Department of Emergency Medical Technology, Seojeong College, Yangju, Republic of Korea.

Abstract

PURPOSE
Many patients who are acutely poisoned with organophosphorus pesticides have co-ingested alcohol. The purpose of this study was to identify the factors that influence mortality in organophosphate intoxication and the differences between alcohol coingested patients and non-coingested patients, looking at vital signs, length of admission, cholinesterase activity, complications, and mortality.
METHODS
All patients visiting one Emergency Department (ED) with organophosphate intoxication between January 2000 and December 2012 were reviewed retrospectively. The patients were divided into two groups, alcohol coingested group and non-coingested group.
RESULTS
During the study period, 136 patients (alcohol coingested group, 95 patients; non-coingested group, 41 patients) presented to the ED with organophosphate intoxication. Seventy-one alcohol coingested patients (74.1%) vs. 16 non-coingested patients (39.0%) received endotracheal intubation, with results of the analysis showing a clear distinction between the two groups (p=0.001). Twenty-three alcohol coingested patients (24.2%) vs. 1 non-coingested patient (2.4%) required inotropics, indicating a significant gap (p=0.002). Twenty-eight alcohol coingested patients (29.5%) vs. 2 non-coingested patients (4.9%) died, with results of the analysis showing a clear distinction between the two groups (p=0.002).
CONCLUSION
In cases of organophosphate intoxication, alcohol coingested patients tended to receive endotracheal intubation, went into shock, developed central nervous system complications, and more died.

Keyword

Organophosphate poisoning; Alcohols; Mortality
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