Tuberc Respir Dis.  2014 Dec;77(6):258-261. 10.4046/trd.2014.77.6.258.

Bilateral Ovarian Metastases from ALK Rearranged Non-Small Cell Lung Cancer

  • 1Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea.
  • 2Department of Pathology, Konkuk University School of Medicine, Seoul, Korea.


Anaplastic lymphoma kinase (ALK) rearrangement, is a kind of driver mutation, accounts for 3%-5% of non-small cell lung cancer (NSCLC). NSCLC patients harboring ALK fusion genes have distinct clinical features and good response to ALK inhibitors. Metastasis from lung cancer to the ovary has rarely been known. We report a case of a 54-year-old woman with bilateral ovarian metastases from ALK rearranged NSCLC. She underwent bilateral salpingo-oophorectomy for ovary masses, which were progressed after cytotoxic chemotherapy although primary lung mass was decreased. Histopathological examination of the ovary tumor showed characteristic adenocarcinoma patterns of the lung and ALK rearrangement.


Anaplastic Lymphoma Kinase; Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis; Ovary

MeSH Terms

Carcinoma, Non-Small-Cell Lung*
Drug Therapy
Lung Neoplasms
Middle Aged
Neoplasm Metastasis*


  • Figure 1 Computed tomography scan showing a 5.4-cm- (A) and 3.3-cm-sized (B) left lower lobe masses with left hilar (C) and subcarinal lymphadenopathies.

  • Figure 2 Bilateral ovarian metastases of lung cancer at the initial positron emission tomography-computed tomography scan showing hypermetabolic activity in both ovaries (maximum standardized uptake value: right 15.7, left 13.4).

  • Figure 3 The ovary showing thick trabeculae or nests of solid variant adenocarcinoma (H&E stain, ×100). Inset: The tumor cells are positive for nuclear immunoreactivity to TTF-1 (×400).

  • Figure 4 (A) The tumor cells of the ovary showing strong ALK immunostaining positivity (×400). (B) Positive split signal patterns using ALK break-apart fluorescent in situ hybridization probe.


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