J Korean Soc Ther Radiol Oncol.  2003 Jun;21(2):107-111.

Outcome of LINAC Radiosurgery for a Cavernous Angioma

• Hong S
• Chie EK
• Park SW
• Kim IH
• Ha SW
• Park CI

Abstract

PURPOSE: To establish the role of stereotactic radiosurgery using a linear accelerator for the treatment of patients with cavernous angioma.
MATERIALS AND METHODS
Between February 1995 and May 1997, 11 patients with cavernous angioma were treated with stereotactic radiosurgery using a linear accelerator. Diagnoses were based on the magnetic resonance imaging in 8 patients, and the histological in 3. The vascular lesions were located in the brainstem (5 cases), cerebellum (2 cases) thalamus (1 case) and cerebrum (3 cases). The clinical presentation at onset included previous intracerebral hemorrhages (9 cases) and seizures (2 cases). All patients were treated with a a linac-based radiosurgery. The median dose of radiation delivered was 16 Gy ranging from 14 to 24 Gy, which was typically prescribed to the 80% isodose surface (range 50~80%), corresponding to the periphery of the lesion with a single isocenter. Ten patients were followed-up.
RESULTS
The median follow-up was 49 months ranging from 8 to 73 months, during which time two patients developed an intracerebral hemorrhage, 1 at 8 months, with the other at 64 months post radiosurgery. One patient developed neurological deficit after radiosurgery, and two developed an edema on the T2 weighted images of the MRI surrounding the radiosurgical target.
CONCLUSION
The use of stereotactic radiosurgery in the treatment of a cavernous angioma may be effective in the prevention of rebleeding, and can be safely delivered. However, a longer follow-up period will be required.

Keyword

Cavernous angioma; Stereotactic radiosurgery

MeSH Terms

Brain Stem
Cerebellum
Cerebral Hemorrhage
Cerebrum
Diagnosis
Edema
Follow-Up Studies
Hemangioma, Cavernous*
Humans
Magnetic Resonance Imaging
Particle Accelerators
Radiosurgery*
Seizures
Thalamus