Korean J Nephrol.
2011 Mar;30(2):178-182.
A Case of Cyclosporine-Induced Type I Renal Tubular Acidosis after Kidney Transplantation
- Affiliations
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- 1Department of Internal Medicine, College of Medicine, Hallym University, Seoul, Korea. km2071@unitel.co.kr
- 2Department of Surgery, College of Medicine, Hallym University, Seoul, Korea.
Abstract
- Cyclosporine is an immunosuppressive agent that plays an important therapeutic role for organ transplantation. However, complications due to type 1 renal tubular acidosis, albeit rare, have been reported. We experienced a case of severe metabolic acidosis associated with cyclosporine administration after renal transplantation. A 54-year old man was hospitalized for seizure, confusion and weakness. He demonstrated severe metabolic acidosis and hypokalemia. Continuous renal replacement therapy was started and sodium bicarbonate was administered to correct the acidosis and the dosage of cyclosporine was reduced. Thereafter, the cyclosporine level in whole blood decreased gradually, and the metabolic acidosis improved.
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