Korean J Anesthesiol.  2011 Jan;60(1):57-59. 10.4097/kjae.2011.60.1.57.

Allergic reactions to hyaluronidase in pain management: A report of three cases

• Kim TW
• Lee JH
• Yoon KB
• Yoon DM

• KMID: 1828001
• DOI: http://doi.org/10.4097/kjae.2011.60.1.57

Abstract

Hyaluronidase has been gaining interest because it reduces tissue edema and fibrosis. Although rare, hyaluronidase has been shown to cause allergic reactions. A few cases of allergic reactions following hyaluronidase administration have been reported. Most of the described patients presented allergic reactions after peribulbar anesthesia for eye surgery. In this report, we describe three patients who experienced with allergic reactions to hyaluronidase following pain management. Two of the patients had a history of uneventful injection with hyaluronidase. All patients were afebrile and blood tests results were normal. Intradermal skin tests were positive. These clinical findings were helpful in establishing the differential diagnosis of infection. Although allergic reaction to hyaluronidase is rare and mostly benign, this must be considered before treating patients.

Keyword

Allergic reaction; Hyaluronidase

MeSH Terms

Anesthesia
Diagnosis, Differential
Edema
Eye
Fibrosis
Hematologic Tests
Humans
Hyaluronoglucosaminidase
Hypersensitivity
Pain Management
Skin Tests
Hyaluronoglucosaminidase