Korean Circ J.  2007 Jun;37(6):235-243. 10.4070/kcj.2007.37.6.235.

The Open Artery Hypothesis

Affiliations
  • 1Cardiology Division, Department of Internal Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea. cmkim@vincent.cuk.ac.kr

Abstract

There is considerable clinical and experimental evidence of the benefit of late reperfusion of infarct-related arteries, referred to as the open artery hypothesis, in patients with acute myocardial infarction who presented too late to salvage at-risk ischemic myocardium. In addition to myocardial salvage, reperfusion of the infarct-related artery prevents infarct expansion, reduces development of ventricular remodeling, and decreases ventricular arrhythmia. The Occluded Artery Trial recently answered a major question related to the open artery hypothesis in a high-risk, asymptomatic patient with an occluded infarct artery. In this review, clinical and experimental evidence of the benefit of the open artery hypothesis will be discussed.

Keyword

Myocardial infarction; Reperfusion; Ventricular remodeling

MeSH Terms

Arrhythmias, Cardiac
Arteries*
Humans
Myocardial Infarction
Myocardium
Reperfusion
Ventricular Remodeling
Full Text Links
  • KCJ
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
    DB Error: unknown error