J Korean Soc Radiol.  2012 Nov;67(5):349-365. 10.3348/jksr.2012.67.5.349.

Korean Society of Thoracic Radiology Guideline for Lung Cancer Screening with Low-Dose CT

Affiliations
  • 1Department of Radiology, Seoul National University Hospital, Seoul, Korea.
  • 2Department of Radiology, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon, Korea. michelan@cnu.ac.kr
  • 3Department of Radiology, Gachon University Gil Medical Center, Incheon, Korea.
  • 4Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • 5Department of Radiology, Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan, Korea.

Abstract

The National Lung Screening Trial (NLST), a nation-wide randomized controlled trial involving more than 50,000 current and former heavy smokers ages 55 to 74, compared the effects of two screening procedures (low-dose helical CT and standard chest radiography) on lung cancer mortality and found 20 percent fewer lung cancer deaths among trial participants screened with low-dose CT. Korean Society of Thoracic Radiology (KSTR) planned to establish an effective guideline for lung cancer screening with low-dose CT to improve health of Korean people and to reduce harms from misuse of lung cancer screening with low-dose CT. KSTR guideline for lung cancer screening with low-dose CT established based on objective medical evidences obtained by NLST.


MeSH Terms

Lung
Lung Neoplasms
Mass Screening
Thorax
Tomography, Spiral Computed

Figure

  • Fig. 1 Estimated New Cancer Cases and Cancer Deaths in the United States (2010). A. Estimated New Cancer Cases in the United States. Lung cancer is the second most common cancer in the States being second only to prostate cancer in men and breast cancer in women (from reference 4). B. Estimated New Cancer Deaths in the United States (2010). Lung cancer is the leading cause of cancer death in both men (29%) and women (26%). The statistical data shows that lung cancer causes the death of 157300 people every year in the United States (from reference 4).

  • Fig. 2 Age-Standardized Death Rates of Cancers in the Korea (2011). Lung cancer becomes the major causes of cancer death from 1999. Lung cancer causes the largest number of cancer deaths in the Korea, accounts for more deaths than stomach cancer and hepatocellular carcinoma (from reference 5).


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Reference

1. Aberle DR, Adams AM, Berg CD, Black WC, Clapp JD, et al. National Lung Screening Trial Research Team. Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med. 2011; 365:395–409.
2. Bach PB, Mirkin JN, Oliver TK, Azzoli CG, Berry DA, Brawley OW, et al. Benefits and harms of CT screening for lung cancer: a systematic review. JAMA. 2012; 307:2418–2429.
3. NCCN Clinical Practice Guidelines in Oncology. Lung Cancer Screening v1.2013. http://www.nccn.org/professionals/physician_gls/f_guidelines.asp.
4. Jemal A, Siegel R, Xu J, Ward E. Cancer statistics, 2010. CA Cancer J Clin. 2010; 60:277–300.
5. Annual Report of the Korea Central Cancer Registry. National Cancer Center Web site. http://www.cancer.go.kr/ncic/cics_g/cics_g02/cics_g027/__icsFiles/afieldfile/2011/12/29/111229.pdf.
6. National Cancer Institute. Non-Small Cell Lung Cancer Treatment (PDQ). Stage 0-4 Non-Small Cell Lung Cancer. 2008. 08. 01. http://www.cancer.gov/cancertopics/pdq/treatment/non-small-cell-lung/HealthProfessional.
7. Chong S, Lee KS, Chung MJ, Kim TS, Kim H, Kwon OJ, et al. Lung cancer screening with low-dose helical CT in Korea: experiences at the Samsung Medical Center. J Korean Med Sci. 2005; 20:402–408.
8. National Lung Screening Trial Research Team. Aberle DR, Berg CD, Black WC, Church TR, Fagerstrom RM, et al. The National Lung Screening Trial: overview and study design. Radiology. 2011; 258:243–253.
9. Patz EF Jr, Caporaso NE, Dubinett SM, Massion PP, Hirsch FR, Minna JD, et al. National Lung Cancer Screening Trial American College of Radiology Imaging Network Specimen Biorepository originating from the Contemporary Screening for the Detection of Lung Cancer Trial (NLST, ACRIN 6654): design, intent, and availability of specimens for validation of lung cancer biomarkers. J Thorac Oncol. 2010; 5:1502–1506.
10. Gohagan J, Marcus P, Fagerstrom R, Pinsky P, Kramer B, Prorok P. Writing Committee, Lung Screening Study Research Group. Baseline findings of a randomized feasibility trial of lung cancer screening with spiral CT scan vs chest radiograph: the Lung Screening Study of the National Cancer Institute. Chest. 2004; 126:114–121.
11. Saghir Z, Dirksen A, Ashraf H, Bach KS, Brodersen J, Clementsen PF, et al. CT screening for lung cancer brings forward early disease. The randomised Danish Lung Cancer Screening Trial: status after five annual screening rounds with low-dose CT. Thorax. 2012; 67:296–301.
12. Pedersen JH, Ashraf H, Dirksen A, Bach K, Hansen H, Toennesen P, et al. The Danish randomized lung cancer CT screening trial--overall design and results of the prevalence round. J Thorac Oncol. 2009; 4:608–614.
13. Sun PL, Seol H, Lee HJ, Yoo SB, Kim H, Xu X, et al. High incidence of EGFR mutations in Korean men smokers with no intratumoral heterogeneity of lung adenocarcinomas: correlation with histologic subtypes, EGFR/TTF-1 expressions, and clinical features. J Thorac Oncol. 2012; 7:323–330.
14. Jang TW, Kim YC, Kwon YS, Oh IJ, Kim KS, Kim SY, et al. Female lung cancer: re-analysis of national survey of lung cancer in Korea, 2005. J Lung Cancer. 2010; 9:57–63.
15. Patel JD. Lung cancer in women. J Clin Oncol. 2005; 23:3212–3218.
16. Sone S, Li F, Yang ZG, Honda T, Maruyama Y, Takashima S, et al. Results of three-year mass screening programme for lung cancer using mobile low-dose spiral computed tomography scanner. Br J Cancer. 2001; 84:25–32.
17. Brenner DJ. Radiation risks potentially associated with low-dose CT screening of adult smokers for lung cancer. Radiology. 2004; 231:440–445.
18. Berrington de González A, Kim KP, Berg CD. Low-dose lung computed tomography screening before age 55: estimates of the mortality reduction required to outweigh the radiation-induced cancer risk. J Med Screen. 2008; 15:153–158.
19. Wahidi MM, Govert JA, Goudar RK, Gould MK, McCrory DC. American College of Chest Physicians. Evidence for the treatment of patients with pulmonary nodules: when is it lung cancer?: ACCP evidence-based clinical practice guidelines (2nd edition). Chest. 2007; 132:3 Suppl. 94S–107S.
20. van Klaveren RJ, Oudkerk M, Prokop M, Scholten ET, Nackaerts K, Vernhout R, et al. Management of lung nodules detected by volume CT scanning. N Engl J Med. 2009; 361:2221–2229.
21. Midthun DE, Swensen SJ, Jett JR, Hartman TE. Evaluation of nodules detected by screening for lung cancer with low dose spiral computed tomography. Lung Cancer. 2003; 41:S40.
22. Henschke CI, Yankelevitz DF, Naidich DP, McCauley DI, McGuinness G, Libby DM, et al. CT screening for lung cancer: suspiciousness of nodules according to size on baseline scans. Radiology. 2004; 231:164–168.
23. Henschke CI, Yankelevitz DF, Mirtcheva R, McGuinness G, McCauley D, Miettinen OS. ELCAP Group. CT screening for lung cancer: frequency and significance of part-solid and nonsolid nodules. AJR Am J Roentgenol. 2002; 178:1053–1057.
24. Lopes Pegna A, Picozzi G, Mascalchi M, Maria Carozzi F, Carrozzi L, Comin C, et al. Design, recruitment and baseline results of the ITALUNG trial for lung cancer screening with low-dose CT. Lung Cancer. 2009; 64:34–40.
25. Aberle DR, Gamsu G, Henschke CI, Naidich DP, Swensen SJ. A consensus statement of the Society of Thoracic Radiology: screening for lung cancer with helical computed tomography. J Thorac Imaging. 2001; 16:65–68.
26. Xu DM, Gietema H, de Koning H, Vernhout R, Nackaerts K, Prokop M, et al. Nodule management protocol of the NELSON randomised lung cancer screening trial. Lung Cancer. 2006; 54:177–184.
27. Act No.65. Ministry of Health and Welfare. [Enforcement Date 27. Jun, 2011].
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