Clin Pediatr Hematol Oncol.
2013 Oct;20(2):121-125.
Early-onset Pericardial Effusion after Autologous Hematopoietic Stem Cell Transplantation in a Child with Neuroblastoma
- Affiliations
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- 1Center for Pediatric Oncology, National Cancer Center, Goyang, Korea. bkpark@ncc.re.kr
- 2Center for Clinical Specialty, Cardiology Clinic, National Cancer Center, Goyang, Korea.
- 3Department of Pediatrics, Myongji Hospital, Goyang, Korea.
Abstract
- Pericardial effusion (PcE) is one of the uncommon complications after hematopoietic stem cell transplantation (HSCT). Although many causes are related with PcE after HSCT, PcE after HSCT is usually late-onset and can be presented as a sign of acute or chronic graft-versus-host disease in allogeneic transplantation. Previous reports of PcE after autologous HSCT are very uncommon. Transplantation-associated thrombotic microangiopathy (TA-TMA) is a kind of renal microvascular complications after HSCT, which is similar to thrombotic thrombocytopenic purpura. The authors report a case of early-onset PcE, which maybe resulted from TA-TMA, after high-dose chemotherapy and autologous peripheral blood HSCT in a 4-year-old child with neuroblastoma.