Endocrinol Metab.  2013 Mar;28(1):3-5. 10.3803/EnM.2013.28.1.3.

Role of Reactive Oxygen Species in Hypothalamic Regulation of Energy Metabolism

• Diano S

• KMID: 1805937
• DOI: http://doi.org/10.3803/EnM.2013.28.1.3

Abstract

To understand the etiology of metabolic disorders, including obesity and type II diabetes, it is essential to gain better insight into how stored and available energy sources are monitored by the central nervous system. In particular, a comprehension of the fine cellular interplay and intracellular mechanisms that enable appropriate hypothalamic and consequent endocrine and behavioral responses to both circulating hormonal and nutrient signals remains elusive. Recent data, including those from our laboratories, raised the notion that reactive oxygen species (ROS) generation is not merely a by-product of substrate oxidation, but it plays a crucial role in modulating cellular responses involved in the regulation of energy metabolism. These review summarizes the published recent data on the effect of ROS levels in the regulation of neuronal function, including that of hypothalamic melanocortin neurons, pro-opiomelanocortin and neuropeptide Y-/agouti related peptide-neurons, in the modulation of food intake.

Keyword

Hypothalamus; Leptin resistance; Peroxisomes; Pro-opiomelanocortin; Reactive oxygen species

MeSH Terms

Central Nervous System
Comprehension
Eating
Energy Metabolism
Hypothalamus
Neurons
Neuropeptides
Obesity
Peroxisomes
Pro-Opiomelanocortin
Reactive Oxygen Species
Neuropeptides
Pro-Opiomelanocortin
Reactive Oxygen Species

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