J Korean Med Sci.  2014 Sep;29(9):1226-1231. 10.3346/jkms.2014.29.9.1226.

Risk Factors for Death during Pulmonary Tuberculosis Treatment in Korea: A Multicenter Retrospective Cohort Study

Affiliations
  • 1Department of Internal Medicine, Chonnam National University Hospital, Gwangju, Korea.
  • 2Department of Pulmonary and Critical Care Medicine, Kyung Hee University Hospital at Gangdong, School of Medicine, Kyung Hee University, Seoul, Korea.
  • 3Division of Pulmonary and Critical Care Medicine, Department of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • 4Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. wjkoh@skku.edu
  • 5Division of Pulmonology, Samsung Changwon Hospital, Changwon, Korea.
  • 6Division of Pulmonary and Critical Care Medicine, Department of Medicine, Ewha Medical Center and Ewha Medical Research Institute, Ewha Womans University School of Medicine, Mokdong Hospital, Seoul, Korea.
  • 7Department of Internal Medicine, Chung-Ang University School of Medicine, Seoul, Korea.
  • 8Department of Internal Medicine, College of Medicine, Gyeongsang Institute of Health Sciences, Gyeongsang National University, Jinju, Korea.

Abstract

The data regarding risk factors for death during tuberculosis (TB) treatment are inconsistent, and few studies examined this issue in Korea. The purpose of this study was to evaluate baseline prognostic factors for death during treatment of adult patients with pulmonary TB in Korea. A multicenter retrospective cohort study of 2,481 patients who received TB treatment at eight hospitals from January 2009 to December 2010 was performed. Successful treatment included cure (1,129, 45.5%) and treatment completion (1,204, 48.5%) in 2,333 patients (94.0%). Unsuccessful treatment included death (85, 3.4%) and treatment failure (63, 2.5%) occurred in 148 patients (6.0%). In multivariate analysis, male sex, anemia, dyspnea, chronic heart disease, malignancy, and intensive care unit (ICU) admission were significant risk factors for death during TB treatment. Therefore, male sex, anemia, dyspnea, chronic heart disease, malignancy, and ICU admission could be baseline prognostic factors for death during treatment of adult patients with pulmonary TB in Korea.

Keyword

Tuberculosis, Pulmonary; Therapeutics; Mortality, Korea

MeSH Terms

Adult
Aged
Anemia/complications
Antitubercular Agents/*therapeutic use
Cohort Studies
Dyspnea/complications
Female
Heart Diseases/complications
Humans
Intensive Care Units
Male
Middle Aged
Multivariate Analysis
Neoplasms/complications
Prognosis
Republic of Korea
Retrospective Studies
Risk Factors
Sex Factors
Treatment Outcome
Tuberculosis/complications/*drug therapy/mortality
Antitubercular Agents

Cited by  1 articles

Treatment of Drug Susceptible Pulmonary Tuberculosis
Hong-Joon Shin, Yong-Soo Kwon
Tuberc Respir Dis. 2015;78(3):161-167.    doi: 10.4046/trd.2015.78.3.161.


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