J Korean Med Sci.  2012 Jan;27(1):46-51. 10.3346/jkms.2012.27.1.46.

Nodal Stations and Diagnostic Performances of Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration in Patients with Non-Small Cell Lung Cancer

• Jhun BW
• Park HY
• Jeon K
• Koh WJ
• Suh GY
• Chung MP
• Kim H
• Kwon OJ
• Han J
• Um SW

• KMID: 1792978
• DOI: http://doi.org/10.3346/jkms.2012.27.1.46

Abstract

There are no accurate data on the relationship between nodal station and diagnostic performance of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA). We evaluated the impact of nodal station and size on the diagnostic performance of EBUS-TBNA in patients with non-small cell lung cancer (NSCLC). Consecutive patients who underwent EBUS-TBNA of mediastinal or hilar lymph nodes for staging or diagnosis of NSCLC were included in this retrospective study. Between May 2009 and February 2010, EBUS-TBNA was performed in 373 mediastinal and hilar lymph nodes in 151 patients. The overall diagnostic sensitivity, specificity, accuracy and negative predictive value (NPV) of EBUS-TBNA were 91.6%, 98.6%, 93.8%, and 84.3%, respectively. NPV of the left side nodal group was significantly lower than those of the other groups (P = 0.047) and sensitivity of the left side nodal group tended to decrease (P = 0.096) compared with those of the other groups. Diagnostic sensitivity and NPV of 4L lymph node were 83.3% and 66.7%, respectively. However, diagnostic performances of EBUS-TBNA did not differ according to nodal size. Bronchoscopists should consider the impact of nodal stations on diagnostic performances of EBUS-TBNA.

Keyword

Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration; Lymph Nodes; Mediastinum; Non-Small Cell Lung Cancer

MeSH Terms

Adult
Aged
Aged, 80 and over
Biopsy, Needle
Bronchoscopy
Carcinoma, Non-Small-Cell Lung/*diagnosis/pathology/ultrasonography
Endosonography
Female
Humans
Lung Neoplasms/*diagnosis/pathology/ultrasonography
Lymph Nodes/pathology
Lymphatic Metastasis
Male
Mediastinum/pathology
Middle Aged
Neoplasm Staging
Positron-Emission Tomography and Computed Tomography
Predictive Value of Tests
Retrospective Studies
Sensitivity and Specificity

Figure

• 

  Fig. 1 Results of lymph nodes sampled by EBUS-TBNA. LN, lymph node; EBUS-TBNA, endobronchial ultrasound-guided transbronchial needle aspiration; CCRT, concurrent chemoradiotherapy.

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