J Korean Med Sci.
2010 Dec;25(12):1792-1797. 10.3346/jkms.2010.25.12.1792.
Desmopressin is an Effective Treatment for Mixed Nocturia with Nocturnal Polyuria and Decreased Nocturnal Bladder Capacity
- Affiliations
-
- 1Department of Integrative Bioscience and Biotechnology, Pohang University of Science and Technology, Pohang, Korea.
- 2Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
- 3Department of Urology, Korea University Anam Hospital, Korea University School of Medicine, Seoul, Korea.
- 4Department of Urology, Keimyung University School of Medicine, Daegu, Korea.
- 5Department of Urology, Seoul National University College of Medicine, Seoul, Korea.
- 6Department of Urology, Pusan National University Hospital, Busan, Korea.
- 7Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. ksleedr@skku.edu
- 8Department of Urology, College of Medicine Inha University, Incheon, Korea.
- KMID: 1792905
- DOI: http://doi.org/10.3346/jkms.2010.25.12.1792
Abstract
- To investigate the efficacy and safety of desmopressin in patients with mixed nocturia, Patients aged > or =18 yr with mixed nocturia (> or =2 voids/night and a nocturnal polyuria index [NPi] >33% and a nocturnal bladder capacity index [NBCi] >1) were recruited. The optimum dose of oral desmopressin was determined during a 3-week dose-titration period and the determined dose was maintained for 4 weeks. The efficacy was assessed by the frequency-volume charts and the sleep questionnaire. The primary endpoint was the proportion of patients with a 50% or greater reduction in the number of nocturnal voids (NV) compared with baseline. Among 103 patients enrolled, 94 (79 men and 15 women) were included in the analysis. The proportion of patients with a 50% or greater reduction in NV was 68 (72%). The mean number of NV decreased significantly (3.20 to 1.34) and the mean nocturnal urine volume, nocturia index, NPi, and NBCi decreased significantly. The mean duration of sleep until the first NV was prolonged from 118.4+/-44.1 to 220.3+/-90.7 min (P<0.001). The overall impression of patients about their quality of sleep improved. Adverse events occurred in 6 patients, including one asymptomatic hyponatremia. Desmopressin is an effective and well-tolerated treatment for mixed nocturia.
MeSH Terms
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Administration, Oral
Adult
Aged
Aged, 80 and over
Antidiuretic Agents/*administration & dosage
Deamino Arginine Vasopressin/*administration & dosage
Drug Administration Schedule
Female
Humans
Male
Middle Aged
Nocturia/complications/*drug therapy
Polyuria/complications/*drug therapy
Prospective Studies
Questionnaires
Sleep/drug effects/physiology
Urinary Bladder/*physiopathology
Urodynamics/physiology
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