J Korean Med Sci.  2014 Jul;29(7):1025-1029. 10.3346/jkms.2014.29.7.1025.

Paradoxical Increase of IgE Binding Components during Allergen-Specific Immunotherapy in Pollinosis Patients

• Kim MA
• Yoon MG
• Jin HJ
• Shin YS
• Park HS

• KMID: 1789967
• DOI: http://doi.org/10.3346/jkms.2014.29.7.1025

Abstract

Allergen-specific immunotherapy (SIT) reduces allergen specific IgE (sIgE) levels and achieves clinical and immunological tolerance by modulating innate and adaptive immunological responses. Increased temperature and CO2 concentrations caused by climate changes contribute to an increase of pollen count and allergenicity that influences clinical SIT outcomes. In this study, we investigated the changes of IgE binding components to tree and weed pollens in pollinosis patients who showed a paradoxical increase of serum sIgE level during pollen-SIT. We enrolled nine patients who showed an increasing pattern of serum sIgE level to alder, birch, ragweed and mugwort pollens by enzyme-linked immunosorbant assay. IgE immunoblot analysis confirmed the intensification or new generation of major IgE binding components that could be induced by climate change. The findings suggest that the regular monitoring of sIgE levels and symptom changes is required to improve the clinical outcomes of SIT in patients undergoing SIT for tree and weed pollens.

Keyword

Pollinosis; Immunotherapy; Specific IgE; Climate Change

MeSH Terms

Adult
Climate Change
*Desensitization, Immunologic
Enzyme-Linked Immunosorbent Assay
Female
Humans
Immunoglobulin E/*blood
Male
Middle Aged
Pollen/immunology
Rhinitis, Allergic, Seasonal/*therapy
Skin Tests
Young Adult
Immunoglobulin E