J Korean Med Sci.  2014 Jul;29(7):941-949. 10.3346/jkms.2014.29.7.941.

Elevated Brachial-Ankle Pulse Wave Velocity Is Independently Associated with Microalbuminuria in a Rural Population

• Seo JY
• Kim MK
• Choi BY
• Kim YM
• Cho SI
• Shin J

• KMID: 1789953
• DOI: http://doi.org/10.3346/jkms.2014.29.7.941

Abstract

Microalbuminuria is a marker of generalized endothelial dysfunction resulting from arterial stiffness or insulin resistance, and brachial-ankle pulse wave velocity (baPWV) is a good measure of arterial stiffness. We aimed to investigate whether elevated baPWV is independently associated with microalbuminuria. This study included 1,648 individuals aged over 40 who participated in the baseline Multi-Rural Cohort Study conducted in Korean rural communities between 2005 and 2006. Participants were classified into less than 30 mg/g as normoalbuminuria or 30-300 mg/g as microalbuminuriausing urinary albumin creatinine ratio (UACR). The median and Q1-Q3 baPWV values were significantly higher in the microalbuminuric group both in men (1,538, 1,370-1,777 cm/s vs. 1,776, 1,552-2,027 cm/s, P < 0.001) and women (1,461, 1,271-1,687 cm/s vs. 1,645, 1,473-1,915 cm/s, P < 0.001). BaPWV was independently associated with microalbuminuria in both genders after adjusting for pulse rate; fasting blood glucose; triglyceride; homeostatic model assessment insulin resistance (HOMA(IR)) and, history of hypertension and diabetes. Fasting blood sugar and HOMA(IR) were judged as having nothing to do with multicolinearity (r = 0.532, P < 0.001). Elevated baPWV was independently associated with microalbuminuria regardless of insulin resistance among rural subjects over 40 yr.

Keyword

Albuminuria; Insulin Resistance; Risk Factors; Vascular Stiffness

MeSH Terms

Adult
Aged
Albuminuria/*diagnosis/etiology/metabolism
Ankle Brachial Index
Ankle Joint/*physiopathology
Blood Chemical Analysis
Blood Glucose/analysis
Brachial Artery/*physiopathology
Cohort Studies
Diabetes Mellitus, Type 2/complications/diagnosis
Female
Humans
Hypertension/complications/diagnosis
Male
Middle Aged
*Pulse Wave Analysis
Risk Factors
*Rural Population
Serum Albumin/analysis
Triglycerides/blood
Vascular Stiffness
Blood Glucose
Serum Albumin
Triglycerides

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