J Korean Med Sci.  2004 Jun;19(3):481-483. 10.3346/jkms.2004.19.3.481.

Widespread Scleredema Accompanied with a Monoclonal Gammopathy in a Patient with Advanced Ankylosing Spondylitis

  • 1Division of Rheumatology, Department of Internal Medicine, Dankook University Hospital, Cheonan, Korea. hanks22@dankook.ac.kr
  • 2Department of Dermatology, Dankook University Hospital, Cheonan, Korea.
  • 3Department of Rehabilitation, Dankook University Hospital, Cheonan, Korea.


Scleredema is a rare cutaneous mucinosis characterized by chronic diffuse induration of the skin, and it is occasionally associated with a monoclonal gammopathy (MG). Ankylosing spondylitis (AS) is noted to be another, chronic systemic inflammatory disorder of the axial skeleton that may accompany the MG. However, patients with scleredema and AS accompanied with a MG have not been reported in the literature. We here report a 40-yr-old man with scleredema and advanced AS accompanied with a MG of IgA-kappa protein. Widespread, long-standing scleredema has been developed over 10 yrs after the initial manifestation of AS. It is uncertain whether the coexistence of scleredema and AS is more than coincidental.


Scleredema Adultorum; Spondylitis, Ankylosing; Gammopathy, Monoclonal; Paraproteinemias
Full Text Links
  • JKMS
export Copy
  • Twitter
  • Facebook
Similar articles
Copyright © 2021 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr