J Korean Med Sci.  2014 May;29(5):714-718. 10.3346/jkms.2014.29.5.714.

Difference of the Naltrexone's Effects in Social Drinkers by Spicy Food Preference

Affiliations
  • 1Department of Psychiatry, Pusan National University Yangsan Hospital, Yangsan, Korea. sungkim@pusan.ac.kr
  • 2Department of Psychiatry, Pusan National University School of Medicine, Yangsan, Korea.
  • 3Department of Psychiatry, Pusan National University Hospital, Busan, Korea.

Abstract

The purpose of this study was to investigate the differences in subjective acute effects of alcohol and naltrexone among those who prefer spicy food to varying degrees. Acute biphasic alcohol effects scale (BAES), visual analogue scale for craving (VAS-C), blood alcohol concentration (BAC) and food preference scale were measured in 26 men. Repeated measures ANOVA (2 preference groupsx4 time blocks) on the stimulative subscale of BAES revealed a significant group by block interaction in naltrexone condition (N+) (P<0.001), but not in non-naltrexone condition (N-). Furthermore, repeated measures ANOVA (2 drug groupsx4 time blocks) on the stimulative subscale of BAES revealed a significant group by block interaction in strong preference for spicy food (SP) (P<0.001), but not in lesser preference for spicy food (LP). The paired t-test revealed that significant suppression of the stimulative subscale of BAES was observed at 15 min (P<0.001) and 30 min (P<0.001) after drinking when N+ compared with N- in SP. For those who prefer spicy food, the stimulative effect of acute alcohol administration was suppressed by naltrexone. This result suggests that the effect of naltrexone may vary according to spicy food preference.

Keyword

Spicy Food Preference; Capsaicin; Naltrexone; Alcohols

MeSH Terms

Adult
Alcohol Drinking/*adverse effects
Alcoholism/*drug therapy
Capsaicin/pharmacology
Food Preferences/*drug effects
Humans
Male
Naltrexone/adverse effects/*therapeutic use
Narcotic Antagonists/adverse effects/*therapeutic use
Questionnaires
Sensory System Agents/pharmacology
Young Adult
Capsaicin
Naltrexone
Narcotic Antagonists
Sensory System Agents

Figure

  • Fig. 1 Total score of 12 stimulative subscale items using the BAES after drinking 0.6 mL/kg of alcohol. BAES, Biphasic Alcohol Effects Scale; LP, lesser preference for spicy food; SP, strong preference for spicy food; N+, naltrexone condition; N-, non-naltrexone condition. *P<0.001 between SP-N+ and SP-N- by paired t-test.


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