J Korean Med Sci.  2014 May;29(5):657-661. 10.3346/jkms.2014.29.5.657.

Prevention of Comorbidity and Acute Attack of Gout by Uric Acid Lowering Therapy

• Joo K
• Kwon SR
• Lim MJ
• Jung KH
• Joo H
• Park W

• KMID: 1786106
• DOI: http://doi.org/10.3346/jkms.2014.29.5.657

Abstract

The object of this study was to evaluate the effect of uric acid lowering therapy in reducing the new development of comorbidities and the frequency of acute attacks in gout patients. We retrospectively reviewed patients who were diagnosed to have gout with at least 3 yr of follow up. They were divided into 2 groups; 53 patients with mean serum uric acid level (sUA)<6 mg/dL and 147 patients with mean sUA> or =6 mg/dL. Comorbidities of gout such as hypertension (HTN), type II diabetes mellitus (DM), chronic kidney disease, cardiovascular disease (CVD) and urolithiasis were compared in each group at baseline and at last follow-up visit. Frequency of acute gout attacks were also compared between the groups. During the mean follow up period of 7.6 yr, the yearly rate of acute attack and the new development of HTN, DM, CVD and urolithiasis was lower in the adequately treated group compared to the inadequately treated group. Tight control of uric acid decreases the incidence of acute gout attacks and comorbidities of gout such as HTN, DM, CVD and urolithiasis.

Keyword

Gout; Hypertension; Diabetes Mellitus; Cardiovascular Diseases; Urolithiasis; Renal Insufficiency; Comorbidity; Allopurinol

MeSH Terms

Adult
Allopurinol/therapeutic use
Antimetabolites/therapeutic use
Benzbromarone/therapeutic use
Cardiovascular Diseases/epidemiology/prevention & control
Comorbidity
Diabetes Mellitus, Type 2/epidemiology/prevention & control
Enzyme Inhibitors/therapeutic use
Female
Gout/*drug therapy/*prevention & control
Gout Suppressants/*therapeutic use
Humans
Hypertension/epidemiology/prevention & control
Male
Middle Aged
Renal Insufficiency, Chronic/epidemiology/prevention & control
Retrospective Studies
Thiazoles/therapeutic use
Uric Acid/*blood/metabolism
Uricosuric Agents/therapeutic use
Urolithiasis/epidemiology/prevention & control
Allopurinol
Antimetabolites
Benzbromarone
Enzyme Inhibitors
Gout Suppressants
Thiazoles
Uric Acid
Uricosuric Agents