J Korean Med Sci.  2008 Oct;23(5):781-788. 10.3346/jkms.2008.23.5.781.

Association of Abdominal Obesity with Atherosclerosis in Type 2 Diabetes Mellitus (T2DM) in Korea

• Cho M
• Park JS
• Nam J
• Kim CS
• Nam JH
• Kim HJ
• Ahn CW
• Cha BS
• Lim SK
• Kim KR
• Lee HC
• Huh KB

• KMID: 1783061
• DOI: http://doi.org/10.3346/jkms.2008.23.5.781

Abstract

The aim of this study was to investigate the relationship between obesity, insulin resistance and atherosclerosis in type 2 diabetes mellitus (T2DM) patients. Total 530 patients with T2DM were included. To evaluate the severity of atherosclerosis, we measured the coronary artery calcification (CAC) score, intima-media thickness (IMT) of the common carotid artery, and the ankle-brachial pressure index (ABPI). Subjects were classified according to body mass index (BMI), a marker of general obesity, and waist-to-hip ratio (WHR), a marker of regional obesity. The insulin sensitivity index (ISI) was measured by the short insulin tolerance test. All subjects were classified into four groups, according to BMI: the under-weight group, the normal-weight (NW) group, the over-weight (OW) group, and the obese (OB) group. WHR and systolic blood pressure, triglycerides (TG), HDL-cholesterol (HDLC), free fatty acids (FFA), fibrinogen, and fasting c-peptide levels were significantly different between BMI groups. TG, HDL-C, FFA, fibrinogen and ISI were significantly different between patients with and without abdominal obesity. In the OW group as well as in the NW group, carotid IMT, ABPI and CAC score were significantly different between patients with and without abdominal obesity. This study indicates that abdominal obesity was associated with atherosclerosis in T2DM patients.

Keyword

Obesity; Insulin Resistance; Diabetes Mellitus Type 2; Atherosclerosis

MeSH Terms

Aged
Atherosclerosis/complications
Blood Pressure
Coronary Vessels/pathology
Diabetes Complications
Diabetes Mellitus, Type 2/*genetics
Female
Humans
Insulin Resistance
Korea
Male
Middle Aged
Obesity/*complications/*genetics
Triglycerides/metabolism
Tunica Intima/pathology
Tunica Media/pathology

Figure

• 

  Fig. 1 The comparison of IMT in subjects between the normal weight group and the over-weight group, with or without abdominal obesity. *p<0.05, compared to subjects without abdominal obesity.

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  Fig. 2 The comparison of ankle-brachial pressure index in subjects between the normal weight group and the over-weight group with or without abdominal obesity. *p<0.05, compared to subjects without abdominal obesity.

• 

  Fig. 3 The comparison of coronary artery calcification score measured by EBT between the normal weight group and the over-weight group with or without abdominal obesity. *p<0.05, compared to subjects without abdominal obesity.

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