J Bacteriol Virol.  2013 Mar;43(1):64-66. 10.4167/jbv.2013.43.1.64.

NLRP6 as a Negative Regulator of Innate Immunity

• Manzoor Z
• Koh YS

• KMID: 1782704
• DOI: http://doi.org/10.4167/jbv.2013.43.1.64

Abstract

Nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs) play important role in immune responses by regulating nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB), type I interferon and inflammasomes. Nod-like receptor pyrin domain-containing protein 6 (NLRP6) is vital for protection of mice from colitis and colorectal tumorigenesis. However, the role of NLRP6 in microbial infection remains unclear. NLRP6 was recently reported as negative regulator of inflammatory signaling and demonstrated that how it hinders clearance of bacterial pathogens.

Keyword

Nod-like receptor pyrin domain-containing protein 6; Inflammasome; Listeria monocytogenes

MeSH Terms

Animals
B-Lymphocytes
Cell Transformation, Neoplastic
Colitis
Cytoskeletal Proteins
Immunity, Innate
Inflammasomes
Interferon Type I
Listeria monocytogenes
Mice
Cytoskeletal Proteins
Inflammasomes
Interferon Type I

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