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J Korean Med Sci.  2006 Apr;21(2):371-373. 10.3346/jkms.2006.21.2.371.

Cutaneous Polyarteritis Nodosa Presented with Digital Gangrene: A Case Report

Affiliations
  • 1Department of Internal Medicine, Ulsan University Hospital, College of Medicine, University of Ulsan, Ulsan, Korea. choisw@uuh.ulsan.kr
  • 2Department of Orthopedic Surgery, Ulsan University Hospital, College of Medicine, University of Ulsan, Ulsan, Korea.
  • 3Department of Pathology, Ulsan University Hospital, College of Medicine, University of Ulsan, Ulsan, Korea.

Abstract

Cutaneous polyarteritis nodosa (CPAN) is an uncommon form of vasculitis involving small and medium sized arteries of unknown etiology. The disease can be differentiated from polyarteritis nodosa by its limitation to the skin and lack of progression to visceral involvement. The characteristic manifestations are subcutaneous nodule, livedo reticularis, and ulceration, mostly localized on the lower extremity. Arthralgia, myalgia, peripheral neuropathy, and constitutional symptoms such as fever and malaise may also be present. We describe a 34-yr-old woman presented with severe ischemic change of the fingertip and subcutaneous nodules without systemic manifestations as an unusual initial manifestation of CPAN. Therapy with corticosteroid and alprostadil induce a moderate improvement of skin lesions. However, necrosis of the finger got worse and the finger was amputated.

Keyword

Polyarteritis Nodosa; Polyarteritis Nodosa; Cutaneous; Gangrene; Amputation

MeSH Terms

Vasodilator Agents/therapeutic use
Skin Diseases, Vascular/*complications/drug therapy/pathology
Polyarteritis Nodosa/*complications/drug therapy/pathology
Humans
Gangrene/*etiology/surgery
Fingers
Female
Amputation
Alprostadil/therapeutic use
Adult
Adrenal Cortex Hormones/therapeutic use
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