Korean J Lab Med.  2010 Dec;30(6):585-590. 10.3343/kjlm.2010.30.6.585.

A Case of Adult B Lymphoblastic Leukemia with ider(9)(q10)t(9;22)(q34;q11.2) and der(19)t(1;19)(q23;p13.3)

• Jung SI
• Cho HS
• Lee CH
• Jung BC

• KMID: 1781663
• DOI: http://doi.org/10.3343/kjlm.2010.30.6.585

Abstract

In B lymphoblastic leukemia/lymphoma (B-ALL/LBL), t(9;22)(q34;q11.2) and t(1;19)(q23;p13.3) are recurrent cytogenetic abnormalities. The concurrent occurrence of both abnormalities is very rare, and only 3 cases have been previously reported. Here, we report a case of adult B-ALL with ider(9)(q10)t(9;22)(q34;q11.2) and der(19)t(1;19)(q23;p13.3). A literature review revealed that ider(9) (q10)t(9;22) is a rare variant of t(9;22) with a deletion of the short arm of chromosome 9. Fifteen cases of ider(9)(q10)t(9;22) have been reported. This abnormality is specific to precursor B-lymphoid neoplasms, such as B-ALL or B-lymphoid blast phase of CML, and is associated with disease progression or short survival. The cytogenetic abnormality t(1;19) is also specific to B-ALL. In most instances of t(1;19), TCF3 is fused to PBX1; however, a few cases have identical translocations but no TCF3-PBX1 fusion, as was observed in our patient. We describe the first case of ider(9)(q10)t(9;22) in combination with TCF3-PBX1 negative t(1;19). The patient underwent imatinib therapy in addition to intensive chemotherapy, but failed to achieve remission.

Keyword

Recurrent cytogenetic abnormalities; B lymphoblastic leukemia; ider(9)(q10)t(9;22); der(19)t(1;19)

MeSH Terms

Bone Marrow Cells/cytology/pathology
Chromosome Deletion
Chromosomes, Human, Pair 1
Chromosomes, Human, Pair 19
Chromosomes, Human, Pair 22
Chromosomes, Human, Pair 9
Female
Fusion Proteins, bcr-abl/genetics/metabolism
Humans
In Situ Hybridization, Fluorescence
Karyotyping
Middle Aged
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/*diagnosis/genetics
*Translocation, Genetic