Ann Lab Med.  2013 May;33(3):225-228. 10.3343/alm.2013.33.3.225.

Plasma Cell Myeloma Initially Presenting as Lung Cancer

Affiliations
  • 1Department of Laboratory Medicine, School of Medicine, Kyung Hee University, Seoul, Korea. 153jesus@hanmail.net
  • 2Department of Hematology-Oncology, School of Medicine, Kyung Hee University, Seoul, Korea.
  • 3Department of Pathology, School of Medicine, Kyung Hee University, Seoul, Korea.
  • 4Department of Nuclear Medicine, School of Medicine, Kyung Hee University, Seoul, Korea.

Abstract

No abstract available.


MeSH Terms

Bone Marrow Cells/pathology
Bone and Bones/radionuclide imaging
Female
Humans
Lung Neoplasms/diagnosis/radiography
Middle Aged
Multimodal Imaging
Multiple Myeloma/*diagnosis/pathology/radiography
Tomography, X-Ray Computed

Figure

  • Fig. 1 Imaging studies. Computed tomography (CT) and positron emission tomography (PET)/CT findings showing the branching out lung mass (A), pleural nodules (B), and paraspinal lesions (C), which were initially interpreted to be suggestive of lung cancer with bone destruction and metastasis. PET/CT reveals multiple hypermetabolic bone lesions (D).

  • Fig. 2 Bone marrow findings. Plasma cells with eccentric nuclei and basophilic cytoplasm were predominantly observed in aspiration smears (A, Wright stain, ×1,000) and clot sections (B, H&E stain, ×1,000). The biopsy sections revealed massive infiltrations of plasma cells (B and C, H&E stain, ×400).

  • Fig. 3 Examinations of the pleural fluid and biopsy. In the cytospin of pleural fluid, plasma cells characterized by basophilic cytoplasm, eccentric nucleus and perinuclear halo were predominantly observed (A, Wright stain, ×1,000). In the pleural biopsy, homogenous infiltrations of plasma cells were identified (B, H&E stain, ×400). Lambda restriction was confirmed (C, immunohistochemical stain, ×400), while kappa was negative (D, immunohistochemical stain, ×400) in the pleural specimen.


Reference

1. Kim YJ, Kim SJ, Min K, Kim HY, Kim HJ, Lee YK, et al. Multiple myeloma with myelomatous pleural effusion: a case report and review of the literature. Acta Haematol. 2008; 120:108–111. PMID: 18957845.
Article
2. Cho SY, Lim G, Oh SH, Lee HJ, Suh JT, Lee J, et al. Primary plasma cell leukemia associated with t(6;14)(p21;q32) and IGH rearrangement: A case study and review of the literature. Ann Clin Lab Sci. 2011; 41:277–281. PMID: 22075513.
3. Kushwaha RA, Verma SK, Mehra S, Prasad R. Pulmonary and nodal multiple myeloma with a pleural effusion mimicking bronchogenic carcinoma. J Cancer Res Ther. 2009; 5:297–299. PMID: 20160366.
Article
4. Nakazato T, Suzuki K, Mihara A, Sanada Y, Kakimoto T. Refractory plasmablastic type myeloma with multiple extramedullary plasmacytomas and massive myelomatous effusion: remarkable response with a combination of thalidomide and dexamethasone. Intern Med. 2009; 48:1827–1832. PMID: 19834276.
Article
5. Ghoshal AG, Sarkar S, Majumder A, Chakrabarti S. Unilateral massive pleural effusion: a presentation of unsuspected multiple myeloma. Indian J Hematol Blood Transfus. 2010; 26:62–64. PMID: 21629638.
Article
6. Cho YU, Chi HS, Park CJ, Jang S, Seo EJ, Suh C. Myelomatous pleural effusion: a case series in a single institution and literature review. Korean J Lab Med. 2011; 31:225–230. PMID: 22016674.
Article
7. Cho SY, Kim Y, Lee A, Park TS, Lee HJ, Suh JT. Three cases showing false results in the detection of monoclonal components using capillary electrophoresis. Lab Medicine. 2011; 42:602–606.
Article
8. Colonna A, Gualco G, Bacchi CE, Leite MA, Rocco M, DeMaglio G, et al. Plasma cell myeloma presenting with diffuse pleural involvement: a hitherto unreported pattern of a new mesothelioma mimicker. Ann Diagn Pathol. 2010; 14:30–35. PMID: 20123454.
Article
9. Riccardi A, Gobbi PG, Ucci G, Bertoloni D, Luoni R, Rutigliano L, et al. Changing clinical presentation of multiple myeloma. Eur J Cancer. 1991; 27:1401–1405. PMID: 1835856.
Article
10. Goździuk K K, Kedra M, Rybojad P, Sagan D. A rare case of solitary plasmacytoma mimicking a primary lung tumor. Ann Thorac Surg. 2009; 87:e25–e26. PMID: 19324112.
11. Ulubay G, Eyübo lu FO, Sim ek A, Ozyilkan O. Multiple myeloma with pleural involvement: a case report. Am J Clin Oncol. 2005; 28:429–430. PMID: 16062090.
12. Goto T, Maeshima A, Oyamada Y, Kato R. Definitive diagnosis of multiple myeloma from rib specimens resected at thoracotomy in a patient with lung cancer. Interact Cardiovasc Thorac Surg. 2010; 10:1051–1053. PMID: 20351017.
Article
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