Yonsei Med J.  2010 Jan;51(1):33-38. 10.3349/ymj.2010.51.1.33.

Endoscopic Evaluation of Gastric Emptying and Effect of Mosapride Citrate on Gastric Emptying

• Jung IS
• Kim JH
• Lee HY
• Park H
• Lee SI

• KMID: 1779603
• DOI: http://doi.org/10.3349/ymj.2010.51.1.33

Abstract

PURPOSE
Gastric emptying has been evaluated by scintigraphy in spite of its limitations of time consumption, cost, and danger of radioisotope. Endoscopy is a simple technique, however, its validation for gastric emptying and quantification of food has not yet been investigated. The aim of our study was to assess endoscopic gastric emptying compared with scintigraphy and radiopaque markers (ROMs) studies. We also investigated the effect of a single dose of mosapride on gastric emptying. MATERIALS AND METHODS: Fifteen healthy volunteers underwent scintigraphy. Next day, subjects received a standard solid meal with ROMs and underwent endoscopy and simple abdomen X-ray after 3 hrs. After one week, the same procedure was repeated after ingestion of mosapride (5 mg for group 1, n = 8; 10 mg for group 2, n = 7) 15 min before the meal. Quantification of gastric residue by endoscopy was scored from 0 to 3, and the scores were added up. RESULTS: All subjects completed the study without any complication. The gastric emptying rate [T1/2 (min)] was in normal range (65.6 +/- 12.6 min). Endoscopic gastric emptying was correlated significantly with gastric clearance of ROMs (r = 0.627, p = 0.012). Endoscopic gastric emptying and gastric clearance of ROMs after administration of mosapride showed significant differences in the 10 mg group (p < 0.05). CONCLUSION: Endoscopy can evaluate gastric emptying safely and simply on an outpatient basis. A 10 mg dose of mosapride enhanced gastric emptying, assessed by both endoscopy and ROMs.

Keyword

Gastric emptying; endoscopy; scintigraphy; radiopaque markers; mosapride

MeSH Terms

Adult
Benzamides/*pharmacology
Endoscopy/*methods
Female
Gastric Emptying/*drug effects
Gastrointestinal Agents/*pharmacology
Humans
Male
Middle Aged
Morpholines/*pharmacology
Radionuclide Imaging/*methods
Stomach/radiography/radionuclide imaging
Young Adult

Figure

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  Fig. 1 Illustrated figure of study protocol. ROMs, radiopaque markers; GE, gastric emptying.

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  Fig. 2 Scoring of endoscopic gastric emptying. (A) Antrum. (B) Body. (C) Fundus. Score; -, O; +, 1; ++, 2; +++, 3.

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  Fig. 3 Correlation between endoscopic gastric emptying and gastric clearance of radiopaque markers (ROMs) (r = 0.627, p = 0.012).

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  Fig. 4 Change of endoscopic gastric emptying and gastric clearance of radiopaque markers (ROMs) after ingestion of 5 mg or 10 mg mosapride citrate. (A) Endoscopic gastric emptying. (a) p = 0.158, (b) p = 0.017, (B) Gastric clearance of ROMs. (a) p = 0.892, (b) p = 0.027.

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