Yonsei Med J.
2007 Apr;48(2):317-320. 10.3349/ymj.2007.48.2.317.
Anticonvulsant Hypersensitivity Syndrome Associated with Epstein-Barr Virus Reactivation
- Affiliations
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- 1Department of Dermatology, Yonsei University College of Medicine, Yongdong Severance Hospital, Seoul, Korea. kimsc@yumc.yonsei.ac.kr
- KMID: 1779537
- DOI: http://doi.org/10.3349/ymj.2007.48.2.317
Abstract
- We describe a 59-year-old female with severe anticonvulsant hypersensitivity syndrome (AHS) associated with Epstein- Barr virus (EBV) infection. The causative drug was speculated to be carbamazepine. Recurrent EBV infection was demonstrated by the presence of anti-EBV early antigen IgM antibodies and anti-EBV nuclear antigen IgG antibodies. To our knowledge, only one case of drug hypersensitivity syndrome (DHS) associated with EBV has been reported in the English- language literature. Our case is the second report of EBV-associated DHS, which suggests that EBV infection may contribute to the pathogenesis of AHS in a few patients.
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