J Korean Med Sci.  2004 Dec;19(6):812-814. 10.3346/jkms.2004.19.6.812.

Alpha-Adducin Gly460Trp Polymorphism and Essential Hypertension in Korea

• Shin MH
• Chung EK
• Kim HN
• Park KS
• Nam HS
• Kweon SS
• Choi JS

• KMID: 1778561
• DOI: http://doi.org/10.3346/jkms.2004.19.6.812

Abstract

Previous studies have suggested that the Gly460Trp polymorphism of the alpha-adducin gene (ADD-1) is associated with salt sensitivity and primary hypertension. The results of linkage or association studies of ADD-1 of different populations are controversial. This study investigated the relationship between the Gly460Trp poly-morphism of ADD-1 and essential hypertension in a Korean population. The subjects (n=903) were participants in a population-based study in Jangseong County, Korea. The Gly460Trp polymorphism of ADD-1 was determined using a polymerase chain reaction method. The frequency of the 460Trp allele was 59.4% in normotensives and 61.1% in hypertensives (p=0.523). The frequencies of the genotypes did not differ significantly between the hypertensive and normotensive groups (16.3% Gly/Gly, 45.8% Gly/Trp, and 38.0% Trp/Trp in normotensives; 16.2% Gly/Gly, 45.8% Gly/Trp, and 38.0% Trp/Trp in hypertensives; p=0.928). After adjusting for other risk factors, Gly/Trp and Trp/Trp were not associated with hypertension (OR 1.00, 95% CI 0.65-1.53, Gly/Trp vs. Gly/Gly; OR 1.22, 95% CI 0.79-1.90, Trp/Trp vs. Gly/Gly). These findings suggest that the Gly460Trp polymorphism of ADD-1 is not associated with hypertension.

Keyword

Hypertension; Adducin; Polymorphism, Single Nucleotide

MeSH Terms

Calmodulin-Binding Proteins/*genetics
DNA Mutational Analysis/methods
Female
Genetic Predisposition to Disease/*epidemiology
Genetic Screening/methods
Humans
Hypertension/*epidemiology/genetics/*metabolism
Korea/epidemiology
Male
Middle Aged
Mutation
Polymorphism, Genetic/genetics
Polymorphism, Single Nucleotide/*genetics
Research Support, Non-U.S. Gov't
Risk Assessment/*methods
Risk Factors

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