J Korean Med Sci.  2010 Mar;25(3):501-504. 10.3346/jkms.2010.25.3.501.

Three Cases of Moraxella osloensis Meningitis: A Difficult Experience in Species Identification and Determination of Clinical Significance

  • 1Department of Laboratory Medicine, Korea University College of Medicine, Seoul, Korea.
  • 2Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea. leekcp@yuhs.ac
  • 3Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.


We had three cases of Moraxella osloensis meningitis. The species identification was impossible by conventional and commercial phenotypic tests. However, we could identify the species using the 16S rRNA gene sequencing. Determination of clinical significance was difficult in one patient. All three patients recovered by appropriate antimicrobial therapy.


Moraxella osloensis; Meningitis; 16S Ribosomal RNA Gene Sequencing

MeSH Terms

Aged, 80 and over
Anti-Bacterial Agents/therapeutic use
*Bacterial Typing Techniques
Child, Preschool
Meningitis, Bacterial/drug therapy/*microbiology
Moraxellaceae Infections/drug therapy/*microbiology
RNA, Bacterial/analysis
RNA, Ribosomal, 16S/analysis
Anti-Bacterial Agents
RNA, Bacterial
RNA, Ribosomal, 16S


1. Schreckenberger PC, Daneshvar MI, Weyant RS, Hollis DG. Murray PR, Baron EJ, Jorgensen JH, Pfaller MA, editors. Acinetobacter, Achromobacter, Chryseobacterium, Moraxella, and other nonfermentative gram-negative rods. Manual of Clinical Microbiology. 2003. Washington: American Society for Microbiology;754–757.
2. Weyant RS, Moss CW, Weaver RE, Hollis DG, Jordan JG, Cook EC, Daneshvar MI. Identification of unusual pathogenic gram-negative aerobic and facultatively anaerobic bacteria. 1995. Baltimore: Williams & Wilkins;390–405.
3. Clarridge JE 3rd. Impact of 16S rRNA gene sequence analysis for identification of bacteria on clinical microbiology and infectious diseases. Clin Microbiol Rev. 2004. 17:840–862.
4. NCCLS. Document M100-S12. Performance Standards for Antimicrobial Susceptibility Testing; Twelfth Informational Supplement. 2002. Wayne, Pa: NCCLS.
5. Graham DR, Band JD, Thornsberry C, Hollis DG, Weaver RE. Infections caused by Moraxella, Moraxella urethralis, Moraxella-like groups M-5 and M-6, and Kingella kingae in the United States, 1953-1980. Rev Infect Dis. 1990. 12:423–431.
6. Sugarman B, Clarridge J. Osteomyelitis caused by Moraxella osloensis. J Clin Microbiol. 1982. 15:1148–1149.
7. Berger U, Kreissel M. Menigitis due to Moraxella osloensis. Infection. 1974. 2:166–168.
8. Fritsche D, Karte H, del Solar E. Moraxella osloensis as pathogen in septicemia. Infection. 1976. 4:53–54.
9. Vuori-Holopainen E, Salo E, Saxen H, Vaara M, Tarkka E, Peltola H. Clinical "pneumococcal pneumonia" due to Moraxella osloensis: case report and a review. Scand J Infect Dis. 2001. 33:625–627.
10. Han XY, Tarrand JJ. Moraxella osloensis blood and catheter infections during anticancer chemotherapy: clinical and microbiologic studies of 10 cases. Am J Clin Pathol. 2004. 121:581–587.
11. Buchman AL, Pickett MJ, Mann L, Ament ME. Central venous catheter infection caused by Moraxella osloensis in a patient receiving home parenteral nutrition. Diagn Microbiol Infect Dis. 1993. 17:163–166.
12. Shah SS, Ruth A, Coffin SE. Infection due to Moraxella osloensis: case report and review of the literature. Clin Infect Dis. 2000. 30:179–181.
13. Rosenthal SL, Freundlich LF, Gilardi GL, Clodomar FY. In vitro antibiotic sensitivity of Moraxella species. Chemotherapy. 1978. 24:360–363.
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