J Korean Med Sci.  2011 Aug;26(8):991-995. 10.3346/jkms.2011.26.8.991.

XRCC1 Polymorphisms and Risk of Papillary Thyroid Carcinoma in a Korean Sample

• Ryu RA
• Tae K
• Min HJ
• Jeong JH
• Cho SH
• Lee SH
• Ahn YH

• KMID: 1777835
• DOI: http://doi.org/10.3346/jkms.2011.26.8.991

Abstract

Polymorphisms of DNA repair genes, X-ray repair cross-complementing group 1 (XRCC1) might contribute to individual susceptibility to different types of cancers. We analyzed the relationship between XRCC1 polymorphisms and the risk of papillary thyroid carcinoma in a Korean sample. A hospital-based case-control study was performed in 111 papillary thyroid carcinoma patients and 100 normal control subjects. XRCC1 Arg194Trp and Arg399Gln single nucleotide polymorphisms (SNPs) were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The XRCC1 Arg194Trp Arg/Trp genotype was significantly associated with a decreased risk of papillary thyroid carcinoma compared to that of Arg/Arg genotype (odds ratio [95% confidence intervals]; 0.550 [0.308-0.983]). There was no significant association between XRCC1 Arg399Gln genotypes and risk of papillary thyroid carcinoma. Based on these results, the XRCC1 Arg194Trp Arg/Trp genotype could be used as a useful molecular biomarker to predict genetic susceptibility for papillary thyroid carcinoma in Koreans.

Keyword

Polymorphisms; XRCC1; SNP; Papillary Thyroid Carcinoma; Susceptibility

MeSH Terms

Adolescent
Adult
Aged
Aged, 80 and over
Amino Acid Substitution
Asian Continental Ancestry Group/*genetics
Case-Control Studies
DNA-Binding Proteins/*genetics
Female
Genetic Predisposition to Disease
Genotype
Humans
Male
Middle Aged
Odds Ratio
Polymorphism, Single Nucleotide
Republic of Korea
Risk Factors
Thyroid Neoplasms/*genetics

Figure

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  Fig. 1 XRCC1 Arg194Trp single nucleotide polymorphism (SNP) by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Arg/Arg genotype, lane 1 and 3; Arg/Trp genotype, lane 2 and 4; Trp/Trp genotype, lane 5.

• 

  Fig. 2 XRCC1 Arg399Gln single nucleotide polymorphism (SNP) by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Arg/Arg genotype, lane 1; Arg/Gln genotype, lane 3 and 4; Gln/Gln genotype, lane 2.

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