J Korean Med Sci.
2013 Oct;28(10):1555-1558. 10.3346/jkms.2013.28.10.1555.
RET Fusion Genes in Korean Non-Small Cell Lung Cancer
- Affiliations
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- 1Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea. jaeyong@knu.ac.kr
- 2Cancer Research Center, Yanbian University School of Basic Medicine, Yanji, China.
- 3Departments of Biochemistry and Cell Biology, Kyungpook National University School of Medicine, Daegu, Korea.
- 4Bio-Medical Research Institute, Kyungpook National University School of Medicine, Daegu, Korea.
- KMID: 1777699
- DOI: http://doi.org/10.3346/jkms.2013.28.10.1555
Abstract
- Recently, rearranged during transfection (RET) fusions have been identified in approximately 1% of non-small cell lung cancer (NSCLC). To know the prevalence of RET fusion genes in Korean NSCLCs, we examined the RET fusion genes in 156 surgically resected NSCLCs using a reverse transcriptase polymerase chain reaction. Two KIF5B-RET fusions and one CCDC6-RET fusion were identified. All three patients were females and never smokers with adenocarcinomas. RET fusion genes were mutually exclusive from EGFR, KRAS mutations and EML4-ALK fusion. RET fusion genes occur 1.9% (3 of 156) of surgically treated NSCLC patients in Koreans.
Keyword
MeSH Terms
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Asian Continental Ancestry Group/*genetics
Carcinoma, Non-Small-Cell Lung/epidemiology/*genetics/surgery
Cytoskeletal Proteins/genetics
Female
Humans
Kinesin/genetics
Lung Neoplasms/epidemiology/*genetics/surgery
Middle Aged
Oncogene Proteins, Fusion/*genetics
Proto-Oncogene Proteins c-ret/*genetics
Republic of Korea/epidemiology
Sequence Analysis, DNA
Cytoskeletal Proteins
Oncogene Proteins, Fusion
Proto-Oncogene Proteins c-ret
Kinesin
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