J Korean Med Sci.  2013 Oct;28(10):1522-1528. 10.3346/jkms.2013.28.10.1522.

Improvement of Dementia Screening Accuracy of Mini-Mental State Examination by Education-Adjustment and Supplementation of Frontal Assessment Battery Performance

Affiliations
  • 1Department of Neuropsychiatry, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Korea.
  • 2Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Korea. selfpsy@snu.ac.kr
  • 3Interdisciplinary Program in Cognitive Science, Seoul National University, Seoul, Korea.
  • 4Department of Neuropsychiatry, Daelim Saint Mary's Hospital, Seoul, Korea.
  • 5Department of Neuropsychiatry, Gyeonggi Provincial Hospital for the Elderly, Yongin, Korea.
  • 6Department of Neuropsychiatry, Kangwon National University Hospital, Chuncheon, Korea.
  • 7Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Korea.

Abstract

This study aimed to investigate whether the demographic variable-adjustment and supplementation of Frontal Assessment Battery (FAB) score can improve the screening ability of Mini-Mental State Examination (MMSE) for dementia and its subtypes. Five hundred forty-one non-demented comparison (NC) and 474 dementia (320 Alzheimer's disease [AD]; 139 non-Alzheimer's disease dementia [NAD]; and 15 mixed AD-NAD dementia) individuals living in the community were included. Education-adjusted MMSE (MMSE-edu) score showed significantly better screening accuracy for overall dementia, AD, and NAD than MMSE raw score. FAB-supplemented MMSE (MMSE-FAB) score had significantly better screening ability for NAD, but not for overall dementia and AD, than MMSE raw score alone. Additional supplementation of FAB to MMSE-edu further increased the ability for overall dementia or NAD screening, but not for AD screening. Further education adjustment of MMSE-FAB also improved its ability for overall dementia, AD, and NAD screening. These results strongly support the usefulness of education-adjustment and supplementation of frontal function assessment to improve screening performance of MMSE for dementia and its subtypes, NAD in particular.

Keyword

Mini-Mental State Examination; Frontal Assessment Battery; Education; Dementia; Screening Accuracy
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